rhBMP-2/PLA复合涂层种植体骨内诱导成骨的实验研究  

Experimental Research of Osteoinductive Activity of rhBMP-2/PLA Composite as a New Kind of Implant Coating Material.

作　　者：程祥荣[1] 杜兵[1] 韩光丽[1] 

机构地区：[1]武汉大学口腔医学院,湖北武汉430079

出　　处：《口腔医学研究》2002年第5期295-296,共2页Journal of Oral Science Research

摘　　要：目的 :观察基因重组人骨形成蛋白 - 2 (recombinanthumanbonemorphogeneticprotein - 2 ,rhBMP - 2 )和聚乳酸 (polylacticacid ,PLA)复合形成的活性涂层种植体骨内诱导成骨活性。 方法 :将rhBMP - 2与聚乳酸复合构建活性涂层种植体 ,植入兔股骨内 ,分别于 4,8,12 ,16周处死动物 ,进行组织学及扫描电镜及组织化学观察 ,检测其成骨活性。结果 :构建的活性涂层种植体具有骨诱导能力 ,PLA为rhBMP - 2的良好控释载体。结论 :rhBMP - 2 /PLA涂层具有良好的生物相容性和骨诱导活性 ,是一种理想的种植体形式。Objective:To study the osteoinductive activity of rhBMP-2/PLA coated implants.Methods:rhBMP-2/PLA coated implants were implanted into the bone of rabbits.After 4,8,12,16weeks,osteoinductive activity of rhBMP-2 was examined by histology and SEM observation.Results:rhBMP-2/PLA coated implant has the osteoinductive activity.PLA could be used as a good carrier and control the delivery of rhBMP-2.Conclusions:rhBMP-2/PLA coating posses definitive biocompatibility and osteoinductivity ,and may be an ideal type of implant coating .

关 键 词：复合涂层种植体 基因重组人内形成蛋白-2 聚乳酸 控释骨架 成骨活性 PLA RHBMP-2 

分 类 号：R782[医药卫生—口腔医学]