BACKGROUND In the medical and dental fields,there is a need for studies of new therapeutic approaches for the treatment of bone defects that cause extensive bone loss.Melatonin may be an important endogenous biologica...
L.L.thanks the Olav Thon Foundation(Grant Number:21-90)for financial support;D.B.R.thanks Maggie-Stephens Foundation(Grant Number:20202004);Sten K Johnson Foundation(Grant Number:2021-0592);The Crafoord Foundation(2021-0550)for research grants.
Recombinant human bone morphogenetic protein-2(rhBMP-2)has been FDA-approved for lumbar fusion,but supraphysiologic initial burst release due to suboptimal carrier and late excess bone resorption caused by osteoclast ...
funded by National Key Research and Development Program of China(No.2016YFC1102900);National Natural Science Foundation of China(No.51772100 and No.32171342);Shanghai Science and Technology Agriculture Project(No.202002080002F01474);Shanghai Pujiang Program(16PJD015);Joint Fund for equipment pre-research of the ministry of education(6141A02022618).
Osteoporosis is a reduction in skeletal mass due to the decrease of osteogenic ability and the activation of the osteoclastic function.Inhibiting bone resorption and accelerating the new bone formation is a promising ...