快速起搏诱发心室颤动过程中的倍周期分岔和浑沌  

Period doubling bifurcation and chaos in the induction of ventricular fibrillation by rapid pacing

作　　者：王雁春[1] 郭姝 李光[1] 冯逵[1] 于德洁[1] 曹济民[1] 

机构地区：[1]中国医学科学院基础医学研究所中国协和医科大学基础医学院生理学系

出　　处：《中华心律失常学杂志》2002年第5期280-284,共5页Chinese Journal of Cardiac Arrhythmias

基　　金：国家自然科学基金资助项目 (3 9970 3 0 0 );国家杰出青年科学基金资助项目 (3 0 12 5 0 16)

摘　　要：目的　探讨室性心动过速 (VT)向心室颤动 (VF)的转化是否表现为浑沌动力学特征。方法用快速起搏法造成犬在体心脏驱动性VT并诱发VF ;用非线性分析方法研究VT向VF转化时 ,心肌电生理学参数的震荡特点。结果　在VT向VF的转化过程中 ,激动周期 (CL)、冲动传导速度 (CV)和R波振幅出现了交替节律、倍周期分岔、半周期等非线性震荡并最终陷入浑沌。结论　驱动性VT向VF的转化遵循非线性途径 。Objective To investigate whether the transition from ventricular tachycardia (VT) to ventricular fibrillation (VF) behaves chaotic dynamics.Methods Driven VT was created and VF was induced by rapid pacing in in situ canine heart.The dynamics of activation cycle length (CL),conduction velocity (CV) and amplitude of R wave were analyzed to access if these dynamics showed non linear and chaotic patterns.Results During the transition from VT to VF,CL,CV and the amplitude of R wave showed alternans,period doubling bifurcation and quasiperiodicity (a sign of chaos).Conclusion The transition from driven VT into VF follows a non linear route.These results provide evidences in in situ heart that VF is chaos.

关 键 词：心室颤动 交替节律 倍周期分岔 浑沌 

分 类 号：R541.7[医药卫生—心血管疾病]