薯蓣皂苷的抗癌机制研究进展  

Progress in Research on Anticancer Mechanism of Dioscin

作　　者：张紫薇[1] 李滢[1] 曹鹏[1] 李晓岩[1] ZHANG Ziwei;LI Ying;CAO Peng;LI Xiaoyan(College of Life Sciences, Northeast Forestry University, Harbin 150040, China)

机构地区：[1]东北林业大学生命科学学院,黑龙江哈尔滨150040

出　　处：《食品科学》2017年第1期297-302,共6页Food Science

基　　金：中央高校基本科研业务费专项(2572014CA23);中国博士后科学基金项目(2013M541328)

摘　　要：研究表明薯蓣皂苷具有良好的抗癌活性,可通过参与线粒体途径和死亡受体途径,对活性氧、B淋巴细胞瘤-2基因家族、细胞周期的调控,对信号通路、相关酶类的调节及细胞分化诱导等方面诱导细胞凋亡,从而起到抗癌作用。本文从薯蓣皂苷逆转多药耐药性、抗炎症作用、基质金属蛋白酶的表达、对表皮生长因子的影响及抑制血管生成等方面阐述薯蓣皂苷的抗癌作用机制,最后对其应用发展前景进行展望,以期为薯蓣皂苷作为抗癌药物的开发提供理论依据。Dioscin has been reported for its good anticancer activity. Dioscin can induce cell apoptosis by regulating reactive oxygen species, B-cell lymphoma 2 family proteins and cell cycle, modulating signaling pathways and enzymes involved in them and stimulating cell differentiation through the mitochondrial pathway and the death receptor pathway, and thus exerts an anticancer effect. This paper reviews the anticancer mechanism of dioscin with respect to reversal of multi-drug resistance, antiinflammatory effect, expression of matrix metalloproteinases, effect on epidermal growth factor and inhibition of angiogenesis.Finally, prospects for the future development and application of dioscin as an anticancer agent are discussed.

关 键 词：薯蓣皂苷 抗癌机制 天然产物 

分 类 号：TS209[轻工技术与工程—食品科学]