环状RNA研究进展及其在口腔疾病中的研究展望  

Research progress of circular RNA and its research prospects in oral diseases

作　　者：曾秉辉[1] 余东升[1] ZENG Bing-hui;YU Dong-sheng(Guanghua School of Stomatology, Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology,Sun Yat.sen University, Guangzhou 510055, China)

机构地区：[1]中山大学光华口腔医学院.附属口腔医院,广东省口腔医学重点实验室,广东广州510055

出　　处：《口腔疾病防治》2017年第2期123-128,共6页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：国家自然科学基金(81272554、81472526);广东省科技计划项目(2016A020216007)

摘　　要：环状RNA(circular RNA)是一类共价闭合环状结构的RNA,具有保守性高、稳定性高、组织特异、广泛存在的特点。环状RNA能发挥mi RNA海绵体的作用,调控相应的通路;能与RNA结合蛋白结合,调控基因的表达;环状RNA在疾病组织中的特异性表达,使它有望成为新的疾病诊断标志物和治疗靶点。本文就环状RNA的研究进展作一综述,并展望其在口腔病方面的研究前景。Circular RNAs(circRNAs)are RNAs with a covalently closed loop structure,characterized by its conser?vation,stability,tissue specific and ubiquity.CircRNAs can serve as miRNA‘sponges’to modulate the mRNA targetsof miRNAs.CircRNAs can bind with RNA binding proteins and regulate the expression of some genes.The differentialexpression of circRNAs between pathogenic and normal tissues makes circRNAs possibly promising biomarkers for diag?nosis and targets for treatment.In this article,we reviewed the research progress of circRNA and discussed its researchprospects in oral diseases.

关 键 词：环状RNA 肿瘤 口腔病 miRNA海绵体 生物标志物 

分 类 号：R78[医药卫生—口腔医学]