吉林人参低聚肽对高脂血症大鼠的影响  

Hypolipidemic Effect of Oligopeptide Derived from Panax ginseng Grown in Jilin Province on Rats with Hyperlipidemia

作　　者：李迪[1] 刘睿[1] 李慧[1] 陈启贺 张召锋[1] 王军波[1] 李勇[1] LI Di;LIU Rui;LI Hui;CHEN Qihe;ZHANG Zhaofeng;WANG Junbo;LI Yong(Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China)

机构地区：[1]北京大学公共卫生学院营养与食品卫生学系,北京100191

出　　处：《食品科学》2017年第5期227-232,共6页Food Science

基　　金："十一五"国家科技支撑计划项目(2006BAD27B08)

摘　　要：目的:观察吉林人参低聚肽(ginseng oligopeptides,GOP)对高脂血症模型大鼠是否具有降脂作用。方法:取SD大鼠108只,设立9个实验组:6个GOP剂量组(0.062 5、0.125 0、0.250 0、0.500 0、1.000 0、2.000 0 g/kg)、1个空白对照组、1个乳清蛋白组(0.250 0 g/kg)和1个模型对照组。空白对照组每日给予基础饲料,其余各组每日给予高脂饲料,2周后各组继续给予相应饲料并连续灌胃30 d。结果:GOP各剂量组大鼠血清胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯含量均无明显变化(P>0.05);GOP能够降低高脂血症大鼠血清和肝脏丙二醛含量(P<0.01),提高血清和肝脏超氧化物歧化酶、谷胱甘肽过氧化物酶活力(P<0.01),升高血清一氧化氮和一氧化氮合酶含量(P<0.01)。结论:GOP没有辅助降血脂作用,GOP可能具有抗动脉硬化作用。Purpose:To investigate the effect of oligopeptide from Panax ginseng grown in Jilin province(GOP)on hyperlipidemic rats.Methods:Totally108specific pathogen free(SPF)male SD rats were randomly divided into9groups:normal control,model,whey protein group,and six GOP groups with different doses.The rats from the normal control group were fed a basal diet only.The rats from the rest groups were fed a high-fat diet for2weeks.Then,the rats in six GOP groups were gavaged with GOP at doses of0.0625,0.1250,0.2500,0.5000,1.0000and2.0000g/kg,respectively,thosein the normal control and model groups with the same volume of distilled water,and those in the whey protein group with whey protein at a dose of0.2500g/kg for30days.At the same time,all rats were provided with the corresponding diets uninterruptedly.Results:The TC,LDL-C,HDL-C and TG levels in serum had no significant change in rats from the GOP groups at each dose.The MDA level was significantly decreased and SOD and GSH-Px activities were significantly elevated in serum and liver tissue of rats from the GOP groups.Besides,serum NO and NOS levels were significantly elevated in the GOP groups.Conclusion:GOP does not has a hypolipidemic effect,but it may have an anti-atherosclerosis effect.

关 键 词：吉林人参低聚肽 SD大鼠 高脂血症 动脉粥样硬化 

分 类 号：R151.2[医药卫生—营养与食品卫生学]