EGCG纳米载体制备技术及其对EGCG活性影响的研究进展  

Progress on the Preparation Technologies and the Active Improvement of EGCG Nano-carriers

作　　者：祁洁[1] 徐颖磊 梁文怡 费朵[1] 乌昕儿 金建昌[2] 杜琪珍[1] 许勇泉[3] 高颖[3] QI Jie;XU Yinglei;LIANG Wenyi;FEI Duo;WU Xiner;JIN Jianchang;DU Qizhen;XU Yongquan;GAO Ying(College of Agriculture and Food Science, Zhejiang Agriculture and Forestry University, Lin'an 311300, China;College of Biological and Environmental Engineering, Zhejiang Shuren University, Hangzhou 310015, China;Tea Research Institute, Chinese Academy of Agricultural Sciences , Hangzhou 310008, China)

机构地区：[1]浙江农林大学农业与食品科学学院,浙江临安311300 [2]浙江树人大学生物与环境工程学院,浙江杭州310015 [3]中国农业科学院茶叶研究所,浙江杭州310008

出　　处：《茶叶科学》2017年第2期119-129,共11页Journal of Tea Science

基　　金：国家大学生创新项目(201610341007);浙江农林大学人才发展基金(2014FR064);国家自然科学基金(31270724)

摘　　要：表没食子儿茶素没食子酸酯(EGCG)是绿茶中最重要的生物活性成分,在肿瘤形成的各个阶段都有抑癌活性。纳米化途径是提高EGCG稳定性和生物利用度的有效技术之一。已有较多的研究表明,多类材料可用于制备纳米粒子作为EGCG载体,并在改善EGCG生物活性方面效果显著。本文按制备纳米粒子主要材料的不同,对各类纳米粒子的制备方法、特性及其在改善EGCG的生物活性方面的研究进行了分述,并对各种纳米粒的增效作用进行了归纳总结。(-)-Epigallocatechin gallate(EGCG)is one of the most important bioactive compounds in green tea,whichhas shown antitumor activity in various stages of tumor formation.Loading EGCG in nano-carriers is an effectivetechnique to improve the stability and bioavailability of EGCG.Many studies had shown that various kinds of materialscan be used for the preparation of nanoparticles as a EGCG nano-carrier,which significantly improved the biologicalactivity of EGCG.The preparation methods,characteristics and the biological activity of EGCG nano-carrier werereviewed,and the improvement of effectiveness by EGCG nanoparticles formulation was also dicussed.

关 键 词：EGCG 纳米粒 材料 制备 生物有效性 

分 类 号：TB383.1[一般工业技术—材料科学与工程] TQ460.1[化学工程—制药化工]