Cell cycle.independent roles of p19INK4d in human terminal erythropoiesis  

作　　者：Xu Han Jing Liu 

机构地区：[1]The State Key Laboratory of Medical Genetics & School of Life Sciences, Central South University, Changsha 410078, Hunan, P. R. China

出　　处：《Chinese Journal of Cancer》2017年第4期163-164,共2页

基　　金：supported in part by the National Natural Science Foundation of China(Grant Nos.81270576 and 81470362)

摘　　要：Normally, cyclin interacts with cyclin-dependent kinase (CDK) to form a cyclin-CDK complex, which promotes cell cycle progression, whereas cyclin-dependent kinase inhibitor (CDKI) molecules inhibit the formation of cyclin- CDK complex, arresting cell cycle. Terminal erythropoiesis is closely coordinated with cell cycle exit, which is regulated by cyclins, CDKs, and CDKIs [1]. In the global transcriptome of human terminal erythropoiesis [2], p19INK4d is expressed highly, and its expression is significantly up-regulated during human terminal erythropoiesis. However, the roles of p19INK4d in terminal erythropoiesis are still unknown.

关 键 词：ROLES ERYTHROPOIESIS CDK 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]