supported by the Massachusetts General Hospital Scientific Projects to Accelerate Research and Collaboration (SPARC) award;Cure Alzheimer’s Fund (to CZ);the National Institutes of Health (NIH),including R01NS102190,RF1NS120947,and R01HL161253 (to MBW),RF1NS120947 (to RJT)。
Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primari...
supported by the State Key Program of National Natural Science Foundation of China(Grant No.32030068);the“Lump-sum System”Project of Chongqing Talent Plan(Grant No.cstc2022ycjh-bgzxm0204).
The island rule,a general pattern of dwarfism in large species to gigantism in small species on islands relative to mainland,is typically seen as a macroevolutionary phenomenon.However,whether the ecological processes...
Supported by the Science and Technology Planning Projects of Guizhou Province,No.QKHJC-ZK[2022]YB642;the Science and Technology Planning Projects of Zunyi City,No.ZSKHHZ(2022)344;the WBE Liver Fibrosis Foundation,No.CFHPC2025028;the Chinese Foundation for Hepatitis Prevention and Control Muxin Research Fund of CHB,No.MX202404;Beijing Liver and Gallbladder Mutual Aid Public Welfare Foundation Artificial Liver Special Fund,No.iGandanF-1082024-Rgg018;the Graduate Research Fund Project of Zunyi Medical University,No.ZYK246;the Student Innovation and Entrepreneurship Training Program of Zunyi Medical University,No.2024106610923 and No.S202310661028.
The complement system is crucial for maintaining immunological homeostasis in the liver,playing a significant role in both innate and adaptive immune responses.Dysregulation of this system is closely linked to the pat...
Supported by Gusu Talent program,No.(2023)105;Suzhou Science and Technology Development Plan Program,No.SKY2023228;Project of Medical Research Fund of Jiangsu Provincial Health Commission,No.Z2023043;Suzhou Clinical Medical Center for Mood Disorders,No.Szlcyxzx202109;Suzhou Clinical Key Disciplines for Geriatric Psychiatry,No.SZXK202116.
Depression is a prevalent mental disorder that affects numerous individuals,manifesting as persistent anhedonia,sadness,and hopelessness.Despite extensive research,the exact causes and optimal treatment approaches for...
Gastric cancer(GC)is one of the most aggressive malignancies worldwide and is characterized by its poor prognosis and resistance to conventional therapies.Autophagy and long non-coding RNAs(lncRNAs)play critical yet c...
supported by Beijing Science and Technology Commission(grant number Z211100002921059);National Science and Technology Major Projects of China(2017ZX10201201-001-006,2017ZX10201201-002-006,and 2018ZX10715-005-003-005);Digestive Medical Coordinated Development Center of Beijing Hospital Authority(XXZ0302 and XXT28);National Key R&D Program China(2022YFC2603505);Beijing Hospital Authority Clinical Medicine Development with Special Funding Support(XMLX 202127);High-Level Public Health Technical Personnel Training Program of Beijing the Municipal Health Commission(2022-3-050);Capital Health Research and Development of Special(2022-1-2172).
Objective Hepatocellular carcinoma(HCC)is sensitive to ferroptosis,a new form of programmed cell death that occurs in most tumor types.However,the mechanism through which ferroptosis modulates HCC remains unclear.This...
supported by Startup Fund for Young Faculty at SJTU(SFYF at SJTU)(No.24X010500176).
As a member of the Cancer-Testis Antigens,the Melanoma-associated antigen(MAGE)family is typically expressed in normal tissues such as the testis.However,in various types of tumor cells,their expression is abnormally ...
This study, which took place around the Boumba-Bek National Park (BBNP) in Cameroon, was based on identifying and characterizing stakeholders in forest resources management, as well as determining the relationships be...
supported by grants from the National Natural Science Foundation of China(grant numbers:82001045,82122014,82020108011,82071085)。
The oral and maxillofacial region is a highly complex area composed of multiple tissue types and bears various critical functions of the human body.Diseases in this region pose significant diagnostic and management ch...
supported by the National Natural Science Foundation of China(No.81901430);the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515010379);the Science and Technology Projects in Guangzhou(No.2023A04J0555);the Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion(No.2021B1212040014),China.
Bone is a highly calcified and vascularized tissue.The vascular system plays a vital role in supporting bone growth and repair,such as the provision of nutrients,growth factors,and metabolic waste transfer.Moreover,th...