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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus
《Neural Regeneration Research》2025年第6期1711-1712,共2页Haoqi Sun Shiqian Shen Robert J.Thomas M.Brandon Westover Can Zhang 
supported by the Massachusetts General Hospital Scientific Projects to Accelerate Research and Collaboration (SPARC) award;Cure Alzheimer’s Fund (to CZ);the National Institutes of Health (NIH),including R01NS102190,RF1NS120947,and R01HL161253 (to MBW),RF1NS120947 (to RJT)。
Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primari...
关键词：ALZHEIMER inflammation HYPOTHESIS 
Utilization of cuproptosis-related lncRNAs to predict the prognosis of pancreatic cancer patients and explore their roles in immune cell infiltration and prognosis evaluation
《Genes & Diseases》2025年第3期39-41,共3页Kaili Liao Jinting Cheng Xiajing Yu Ziqian Liu Xue Zhang Yuxin Fu Wenyige Zhang Jie Liu Feifei Teng Yuxuan Xie Xiwen Yan Gaoquan Cao Bing Sun Hanqing Zhao Jingyan Zhang Xiaozhong Wang 
funded by the National Natural Science Foundation of China(No.82160405).
The prognosis of pancreatic cancer(PC)is difficult to predict1 and is extremely poor.2 Studies showed that cuproptosis was related to PC.The roles are not completely understood.It is considered that lncRNAs are closel...
关键词：pearson correlation analysis immune cell infiltration univariate cox regression analysis lncRNAs cuproptosis pancreatic cancer pancreatic cancer pc PROGNOSIS 
Transcription factor ELF4 in physiology and diseases:Molecular roles and clinical implications
《Genes & Diseases》2025年第3期329-346,共18页Dian Hu Zerui Zhang Yijun Wang Siwen Li Jiaqian Zhang Zhangfan Wu Mengyu Sun Junqing Jiang Danfei Liu Xiaoyu Ji Shuai Wang Yufei Wang Xiangyuan Luo Wenjie Huang Limin Xia 
funded by the National Natural Science Foundation of China(No.U23A20451,82273310,82372917,82173313);the Natural Science Foundation of Hubei Province,China(No.2022CFA016);the Basic Research Support Program of Huazhong University of Science and Technology(China)(No.2023BR038).
Transcription factor E74 like ETS transcription factor 4(ELF4),a member of the ETS family,is highly expressed in normal human hematopoietic tissue,ovary,placenta,colon,and certain pathological cell lines.During normal...
关键词：BIOMARKER Cancer ELF4/MEF Immune system METASTASIS 
Prognostic significance and multidimensional roles of interferon regulatory factors in cancer biology:A comprehensive analysis
《Genes & Diseases》2025年第3期15-18,共4页Guo Ji Shuyuan Xian Jiaqi Song Shiyu Mao Man Pi Qiongyi Huang Xue Han Jian Yin Zan Wu Runzhi Huang Dongyan Han Zhengyan Chang 
supported in part by the National Natural Science Foundation of China(No.82002923,82203505).
Interferon regulatory factors(IRFs)are transcription factors with a conserved N-terminal helix-loop-helix DNA-binding domain 1.IRF family plays a pivotal role in regulating interferon transcription,immune cell develop...
关键词：interferon regulatory factors irfs interferon regulatory factors multidimensional correlation analysiswe multidimensional roles STEMNESS transcription factors immune subtype cancer biology 
Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy
《Oncology Research》2025年第5期1007-1017,共11页MOEKA NAKASHIMA NAOKO SUGA AKARI FUKUMOTO SAYURI YOSHIKAWA SATORU MATSUDA 
Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation,invasion,metastasis,and/or recurrence of their malignancies.In particular,cancer stem cells(CSCs)within these tumors might b...
关键词：Vitamin D Cancer stem cell INVASION METASTASIS CHEMORESISTANCE Ferroptosis Tumor microenvironment Noncoding RNAs Cancer therapy 
Multifaceted roles of UFMylation in health and disease
《Acta Pharmacologica Sinica》2025年第4期805-815,共11页Ru-na Wang Lin Li Jun Zhou Jie Ran 
supported by grants from the National Natural Science Foundation of China(32241014 and 32170687).
Ubiquitin fold modifier 1(UFM1)is a newly identified post-translational modifier that is involved in the UFMylation process.Similar to ubiquitination,UFMylation enables the conjugation of UFM1 to specific target prote...
关键词：UFMylation UFM1 post-translational modification DISEASE therapeutic target 
Analysis of the roles of MAD proteins in the wing dimorphism of Nilaparvata lugens
《Insect Science》2025年第2期515-529,共15页Miaomiao Tian Zeiwei Lu Jiguang Luo Huilin Han Dong Wen Muhua Zhao Zhihui Zhu Hongxia Hua 
supported by a grant from the National Natural Science Foundation of China(32172396).
Wing dimorphism in Nilaparvata lugens is controlled by the insulin-like growth factor 1(IGF-1)signaling–Forkhead transcription factors(IIS-FoxO)pathway.However,the role of this signal in the wing development program ...
关键词：IIS-FoxO pathway Nilaparvata lugens NlmadI Nlmad2 wing dimorphism 
The island rule-like patterns of plant size variation in a young landbridge archipelago:Roles of environmental circumstance and biotic competition
《Plant Diversity》2025年第2期300-310,共11页Zengke Zhang Wensheng Chen Zengyan Li Wentao Ren Ling Mou Junyong Zheng Tian Zhang Hantang Qin Liyi Zhou Bile Sai Hang Ci Yongchuan Yang Shekhar RBiswas Enrong Yan 
supported by the State Key Program of National Natural Science Foundation of China(Grant No.32030068);the“Lump-sum System”Project of Chongqing Talent Plan(Grant No.cstc2022ycjh-bgzxm0204).
The island rule,a general pattern of dwarfism in large species to gigantism in small species on islands relative to mainland,is typically seen as a macroevolutionary phenomenon.However,whether the ecological processes...
关键词：Insular dwarfism and gigantism Island biogeography The environmental stress hypothesis The reduced herbivory hypothesis The relaxed competition hypothesis The resource availability hypothesis 
Ruminal‑buccal microbiota transmission and their diagnostic roles in subacute rumen acidosis in dairy goats
《Journal of Animal Science and Biotechnology》2025年第2期895-912,共18页Tao Liu Jingyi Xu Xiaodong Chen Jianrong Ren Jinhui He Yue Wang Yangchun Cao Le Luo Guan Junhu Yao Shengru Wu 
supported by the National Key Research and Development Program for International Science and Technology Innovation Cooperation between Governments(2023YFE0111800);the Shaanxi Province’s San Qin Talent Attraction Program for Regional Youth Talents.
Background Subacute rumen acidosis(SARA)is a common metabolic disorder in ruminants that disrupts the rumen microbiome and animal health,but diagnosis is challenging due to subtle symptoms and invasive testing require...
关键词：Dairy goats Diagnosis Oral microbiota Ruminal microbiota Subacute rumen acidosis 
Anisotropic flow,flow fluctuation,and flow decorrelation in relativistic heavy-ion collisions:the roles of sub-nucleon structure and shear viscosity
《Chinese Physics C》2025年第4期90-100,共11页Jie Zhu Xiang-Yu Wu Guang-You Qin 
Supported in part by the Natural Science Foundation of China(12225503,11890710,11890711,11935007);Zhu Jie is supported in part by the China Scholarship Council(202306770009);Wu Xiang-Yu is supported in part by the National Science Foundation within the framework of the JETSCAPE collaboration(OAC-2004571);in part by the Natural Sciences and Engineering Research Council of Canada.Some of the calculations were performed in the Nuclear Science Computing Center at Central China Normal University(NSC3),Wuhan,Hubei,China.
We study the transverse momentum(pr)differential anisotropic flow and flow fluctuation in Pb+Pb collisions at√S_(NN)=5.02 TeV at the LHC.A(3+1)-dimensional CLVisc hydrodynamics framework with fluctuating TRENTO(or AM...
关键词：heavy-ion collisions relativistic hydrodynamics anisotropic flow flow fluctuation fow decorrelation sub-nucleon structure shear viscosity 
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