Transcription factor ELF4 in physiology and diseases:Molecular roles and clinical implications  

作　　者：Dian Hu Zerui Zhang Yijun Wang Siwen Li Jiaqian Zhang Zhangfan Wu Mengyu Sun Junqing Jiang Danfei Liu Xiaoyu Ji Shuai Wang Yufei Wang Xiangyuan Luo Wenjie Huang Limin Xia 

机构地区：[1]Department of Gastroenterology,Institute of Liver and Gastrointestinal Diseases,Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China [2]Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases,Hepatic Surgery Center,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Clinical Medicine Research Center for Hepatic Surgery of Hubei Province,Key Laboratory of Organ Transplantation,Ministry of Education and Ministry of Public Health,Wuhan,Hubei 430030,China [3]Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province,Department of Hepatobiliary and Pancreatic Surgery,Affiliated Hangzhou First People’s Hospital,Westlake University School of Medicine,Hangzhou,Zhejiang 310006,China [4]State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases,Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi’an,Shannxi 710032,China

出　　处：《Genes & Diseases》2025年第3期329-346,共18页基因与疾病(英文)

基　　金：funded by the National Natural Science Foundation of China(No.U23A20451,82273310,82372917,82173313);the Natural Science Foundation of Hubei Province,China(No.2022CFA016);the Basic Research Support Program of Huazhong University of Science and Technology(China)(No.2023BR038).

摘　　要：Transcription factor E74 like ETS transcription factor 4(ELF4),a member of the ETS family,is highly expressed in normal human hematopoietic tissue,ovary,placenta,colon,and certain pathological cell lines.During normal physiological processes,ELF4 regulates differentiation in osteogenic,adipocyte,and neuronal types.It also exerts a critical impact on the development of the immune system.However,its function is dysregulated through posttranslational modifications,gene fusions,and complex signaling crosstalk under pathological conditions.Furthermore,serving as a double-edged sword in cancer,ELF4 exhibits both tumorsuppressing and tumor-promoting effects.Specifically,ELF4 plays a critical role in cancer metastasis,proliferation,and modulation of the tumor microenvironment.This review provides an in-depth overview of the molecular structure and post-translational modifications of ELF4.It also summarizes the hallmarks of ELF4 in physiology and diseases,with a particular focus on its significance in oncology.Notably,this review underscores the potential of ELF4 as a prognostic biomarker,highlighting its clinical relevance.Finally,it discusses unresolved questions and future research directions of ELF4.An in-depth understanding of ELF4 biology could facilitate its clinical translation and offer promising targeted therapeutic strategies.

关 键 词：BIOMARKER Cancer ELF4/MEF Immune system METASTASIS 

分 类 号：R730.2[医药卫生—肿瘤]