Nicotinamide adenine dinucleotide phosphate promote the rapid growth of the tumor  

作　　者：Sheng Hao 

机构地区：[1]The First Affiliated Hospital, Biomedical Translational Research Institute, Jinan University,Guangzhou,Guangdong 510632, China

出　　处：《国际感染病学（电子版）》2017年第2期57-59,共3页Infection International(Electronic Edition)

摘　　要：Nicotinamide adenine dinucleotide phosphate(NADPH) oxidase is the main source of ROS(intracellular reactive oxygen species), ROS plays an important role in a variety of tumor, the ROS mediated by NADPH oxidase increase the expression of hypoxia inducing factor alpha(HIF-α) through multiple signaling pathways in tumor, and HIFcould be regulated and controlled by downstream multiple targeted genes such as vascular endothelial growth factor(VEGF), glucose transporter(GLUT) to promote tumor angiogenesis, cell energy metabolism reprogram and tumor metastasis.HIF-α, meanwhile, also can regulate the expression of NADPH oxidase by ROS, thus further promote development of tumor.In this review, we will summarize the functions of NADPH in tumorigenesis and discuss their potential implications in cancer therapy.Nicotinamide adenine dinucleotide phosphate(NADPH) oxidase is the main source of ROS(intracellular reactive oxygen species), ROS plays an important role in a variety of tumor, the ROS mediated by NADPH oxidase increase the expression of hypoxia inducing factor alpha(HIF-α) through multiple signaling pathways in tumor, and HIFcould be regulated and controlled by downstream multiple targeted genes such as vascular endothelial growth factor(VEGF), glucose transporter(GLUT) to promote tumor angiogenesis, cell energy metabolism reprogram and tumor metastasis.HIF-α, meanwhile, also can regulate the expression of NADPH oxidase by ROS, thus further promote development of tumor.In this review, we will summarize the functions of NADPH in tumorigenesis and discuss their potential implications in cancer therapy.

关 键 词：PENTOSE PHOSPHATE pathway METABOLIC flow BIOSYNTHESIS ROS HIF - 1a HIF - 2a 

分 类 号：R730.2[医药卫生—肿瘤]