Role of SR-BI in atherosclerosis, malignancies, and infectious diseases  

作　　者：Zhe An 

机构地区：[1]Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, P.R. China

出　　处：《国际感染病学（电子版）》2017年第3期65-69,共5页Infection International(Electronic Edition)

摘　　要：Scavenger receptor class B type Ⅰ(SR-BI) is a high-affinity receptor for high-density lipoprotein(HDL). The primary role of this receptor is the selective uptake of HDLs in the liver through reverse cholesterol transport. SR-BI interacts with HDL to regulate lipid metabolism and affect various vascular cell functions involved in atherosclerosis(As). In addition, SRBI is involved in the development of malignant tumors and infectious diseases. This article reviews the function and potential therapeutic targets of SR-BI in As, malignancies, and infectious diseases.Scavenger receptor class B type Ⅰ(SR-BI) is a high-affinity receptor for high-density lipoprotein(HDL). The primary role of this receptor is the selective uptake of HDLs in the liver through reverse cholesterol transport. SR-BI interacts with HDL to regulate lipid metabolism and affect various vascular cell functions involved in atherosclerosis(As). In addition, SRBI is involved in the development of malignant tumors and infectious diseases. This article reviews the function and potential therapeutic targets of SR-BI in As, malignancies, and infectious diseases.

关 键 词：SCAVENGER receptor class B  type I High-density LIPOPROTEIN ATHEROSCLEROSIS Malignant neoplasms 

分 类 号：R51[医药卫生—内科学] R543.5[医药卫生—临床医学] R730