齐墩果酸的来源及护肾作用研究进展  

Advances in Research of the Origin of Oleanolic Acid and its Renal Protection

作　　者：廖忻 陈文莹 杨杰也琦 李晓红[3] 李晨 谌小立[1,2] Liao Xin(School of Public Health,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医学院公共卫生学院,贵州遵义563000 [2]贵州省预防医学实验教学示范中心,贵州遵义563000 [3]北京农业职业学院,北京102442

出　　处：《安徽农学通报》2018年第6期156-160,共5页Anhui Agricultural Science Bulletin

基　　金：市校联合项目(遵市科合社字(2017)18号);贵州省科学技术基金重点项目(黔科合LH字[2014]7546号);北京农业职业学院院级项目(XY-YT-16-44);遵义医学院优秀青年人才项目(17zy-006);遵义医学院博士学位授权支撑学科建设经费

摘　　要：齐墩果酸是一种生物活性五环三萜类化合物,广泛存在于世界各地的食源性或药用草本植物中,如葡萄、柿子、蓝莓、樱桃、木瓜、山楂、大枣和枇杷等。目前的研究表明,齐墩果酸对糖尿病性肾病、高血压性肾损伤、肾纤维化、多囊肾病、药物诱导的肾损伤、重金属诱导的肾损伤、缺血再灌注肾损伤和移植肾损伤均有一定的保护作用。该文对齐墩果酸的来源及护肾作用的研究进展进行了综述。Oleanolic acid is a bioactive pentacyclic triterpenoid and is widely found in food-borne or medicinal herbs around the world,such as grapes,persimmons,blueberries,cherries,papaya,hawthorn,jujube and loquat and so on.Current researches indicated that oleanolic acid had a certain degree of protective effects on diabetic nephropathy,hypertensive renal injury,renal fibrosis,polycystic kidney disease,drug-induced renal injury,heavy metal-induced renal injury,is chemia-reperfusion renal injury and renal allograft injury.The origin of oleanolic acid and its renal protection was reviewed in present article.

关 键 词：齐墩果酸 食物来源 肾脏保护 肾损伤 

分 类 号：R285[医药卫生—中药学]