Gray Matter Volume Changes over the Whole Brain in the Bulbar-and Spinal-onset Amyotrophic Lateral Sclerosis: a Voxel-based Morphometry Study  

延髓发病型及脊髓发病型肌萎缩侧索硬化症脑部磁共振结构特征变化（英文）

作　　者：陈志晔 刘梦琦 马林 

机构地区：[1]解放军总医院放射科 [2]解放军总医院海南分院放射科

出　　处：《Chinese Medical Sciences Journal》2018年第1期20-28,共9页中国医学科学杂志（英文版）

基　　金：Supported by the grant of the National Natural Sciences Foundation of China(30470512)

摘　　要：Objective To investigate cerebral structural signatures of the bulbar-and spinal-onset amyotrophic lateral sclerosis(ALS) using voxel-based morphometry on magnetic resonance imaging.Methods The MR structural images of the brain were obtained from 65 ALS patients(15 bulbar-onset, 50 spinalonset) and 65 normal controls(NC) on a 3.0 T MRI system. Gray matter(GM) volume changes were investigated by voxel-based morphometry, and the distribution of the brain regions with volume changes was compared between ALS and normal controls, as well as between bulbar-onset and spinal-onset ALS based on Neuromorphometrics atlas.Results On voxel-level the decreased volume of brain regions in ALS patients was located in the right precentral gyrus(r Prc Gy) and right middle frontal gyrus compared with that in NC. The bulbar-onset ALS presented extramotor cortex atrophy(fronto-temporal pattern), including left medial orbital gyrus, left inferior temporal gyrus and right middle temporal gyrus; the spinal-onset ALS suffered from motor cortex atrophy(r Prc Gy dominance) and extra-motor cortex atrophy(fronto-temporal and extra-fronto-temporal pattern) compared with NC. The spinal-onset ALS featured by GM volume loss of left postcentral gyrus and bulbar-onset ALS featured by GM volume loss of left middle temporal gyrus compared with each other. Conclusions The asymmetric GM atrophy of the motor cortex and extra-motor cortex represents the common MRI structural signatures of spinal-onset ALS, and sole extra-motor cortex atrophy represents the structural signatures of bulbar-onset ALS. The present study also demonstrated that the pattern of GM damage is likely to distribute wider in spinal-onset ALS than in bulbar-onset ALS.

关 键 词：amyotrophic lateral SCLEROSIS GRAY matter magnetic resonance imaging precentral GYRUS voxel-based MORPHOMETRY 

分 类 号：R[医药卫生]