没食子酸衍生物的合成及抑菌活性研究  

Synthesis of Gallic Acid Derivatives and Their Antibacterial Activities

作　　者：谭平 刘斯宇 周太平 孙冬梅 彭长江 杜波[2] 任丹[2] 杨锡良[2] 王周玉 DU Bo;REN Dan;YANG Xiliang;WANG Zhouyu(School of Science,Xihua University,Chengdu 610039 China;Chengdu Newsun Crop Science Co.,Ltd,Chengdu 610039 China)

机构地区：[1]西华大学理学院,四川成都610039 [2]成都新朝阳作物科学有限公司,四川成都610039

出　　处：《西华大学学报（自然科学版）》2018年第2期108-112,共5页Journal of Xihua University:Natural Science Edition

基　　金：教育部“春晖”项目(Z2016162);四川省重点研发项目(2017NZ0048)

摘　　要：利用植物源农药中活性较高的天然产物为先导化合物进行结构改造和优化是研究低毒、新型农药的重要方向。本文以没食子酸为原料通过保护、酰化、脱保护等反应合成4个结构全新的没食子酸衍生物,衍生物经过~1H NMR、^(13)C NMR和HRMS进行了结构表征。同时研究了4种化合物对苹果斑点落叶病菌、苹果轮纹病菌、立枯丝核菌病菌以及马铃薯晚疫病菌的杀菌效果。Modification and optimization of natural compounds with higher activity in botanic pesticides are important directions in the field of pesticides.In this paper,four novel gallic acid derivatives were synthesized through the formation of protecting group,acylation,deprotection reaction with the gallic acid as the raw material.The final products were confirmed by 1H NMR,13 C NMR and HRMS.In addition,the antibacterial activities of four compounds on Ahernaria mali,Physalospora Piricola,Rhizoctonia solani and Phytophthora infestans were studied.

关 键 词：没食子酸 植物源农药 衍生物 抑菌活性 新型农药 

分 类 号：Q624[生物学—生物物理学]