动态监测胃癌患者手术治疗前后血清VEGF、SE-CAD、HCY、TNF-α水平变化及意义  

The clinical significance of dynamic monitoring of VEGF,SE-CAD,HCY and TNF-α in serum levels in patients with gastric cancer

作　　者：程海涛 熊春容 袁中海 CHENG Hai-tao;XIONG Chun-rong;YUAN Zhong-hai(Department of Clinical Laboratory,Ezhou Second Hospital,Hubei,Ezhou 436000,China;Surgical Department,Ezhou Second Hospital,Hubei,Ezhou 436000,China)

机构地区：[1]湖北省鄂州二医院检验科,湖北鄂州436000 [2]湖北省鄂州二医院外科,湖北鄂州436000

出　　处：《海南医学院学报》2018年第3期380-382,386,共4页Journal of Hainan Medical University

基　　金：2015湖北省卫计委面上项目(JX614K)~~

摘　　要：目的:通过监测血清血管内皮生长因子(VEGF)、可溶性上皮型钙黏附蛋白(SE-CAD)、同型半胱氨酸(Hcy)、肿瘤坏死因子(TNF-α)在胃癌患者手术治疗前后水平变化,探讨其在临床疗效观察及预后评估中的意义。方法:选择本院收治的94例胃癌患者为研究对象,另选同期体检健康者60例为对照,测定血清Hcy,VEGF、SE-CAD、TNF-α水平,观察治疗前后指标变化,并分析其与预后关系。结果:血清Hcy、VEGF、SE-CAD、TNF-α水平胃癌组高于对照组,手术治疗后1个月水平降低,但仍高于对照组(P<0.05);术后3个月血清Hcy、SE-CAD、TNF-α水平将至正常范围,VEGF仍高于正常范围;术后随访3年,复发组血清Hcy、VEGF、SE-CAD、TNF-α水平明显高于未复发组(P<0.05)。结论:胃癌患者手术治疗前后血清Hcy、VEGF、SE-CAD、TNF-α水平变化与疾病病情及预后相关,动态监测其水平变化有助于病情监测及预后评估。Objective:This aim was to investigate the clinical significance of dynamic monitoring of VEGF,SE CAD,HCY and TNFαin serum levels in patients with gastric cancer.Methods A total of 94 patients with gastric cancer treated in our hospital from February 2013 to September 2014 were selected as the subjects.Sixty healthy subjects were selected as control group.VEGF,SE CAD,HCY and TNFαin serum levels were measured by cyclic enzyme method and enzyme linked immunosorbent assay(ELISA).The correlation between the serum index and prognosis was analyzed.Results The levels of Hcy,VEGF,SE CAD and TNFαin serum of gastric cancer group were significantly higher than those in control group(P<0.05).1 month after surgery,levels of Hcy,VEGF,SE CAD and TNFαwere still higher than those in control group(P<0.05).3 months after surgery,Hcy,SE CAD,TNFαlevels reached to the normal range,while VEGF was still higher than the normal range(P<0.05).The levels of Hcy,VEGF,SE CAD and TNFαin relapse group were significantly higher than those in non recurrence group after 3 years of follow up.Conclusion The results show that the changes of serum Hcy,VEGF,SE CAD and TNFαlevel in patients with gastric cancer before and after operation were related to the disease condition and prognosis.The dynamic monitoring of the changes of Hcy,VEGF and TNFαwas helpful to the observation and prognosis.

关 键 词：胃癌 HCY VEGF SE CAD TNFΑ 

分 类 号：R735.2[医药卫生—肿瘤]