线粒体治疗在线粒体相关疾病治疗中的应用及展望  

Application and prospect of mitotherapy in mitochondria-related diseases

作　　者：张华菁 赵孟楠 付琛[1] 付爱玲[1] ZHANG Hua-jing;ZHAO Meng-nan;FU Chen;FU Ai-ling(College of Pharmaceutical Sciences,Southwest University,Chongqing　400715,China)

机构地区：[1]西南大学药学院,重庆400715

出　　处：《中国药理学通报》2018年第4期459-463,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81273416)

摘　　要：线粒体是哺乳动物细胞中供应能量、维持胞内稳态等多种功能的细胞器。目前已知有上百种疾病与线粒体功能缺陷有关。研究表明,外源线粒体可直接进入哺乳动物细胞,并可通过局部注射或静脉注射快速转移到动物或人体细胞内。线粒体治疗(mitotherapy)是通过将正常有功能的线粒体移植到具有线粒体缺陷的细胞中,从而对相关疾病进行防治的新策略。移植的线粒体在受体细胞内可发挥能量生成、维持自由基平衡、恢复细胞活力等功能。由于目前对线粒体相关疾病尚缺乏有效的治疗方法,线粒体治疗将为其防治提供一个新的途径。Mitochondria is an important organelle in mammalian cells with multiple functions,such as energy production and cell homeostasis maintaining.It is known that hundreds of diseases are associated with mitochondrial defects.The studies show that the exogenous mitochondria can directly enter mammalian cells in vitro,and they also can quickly transform into animal tissues by local or intravenous injection.Currently,it has raised a new therapeutic strategy for mitochondrial diseases,called mitotherapy,which transplants exogenous functional mitochondria into mitochondria-defective cells.The mitochondria in recipient cells play their own roles,including energy production,maintaining free radical balance,and cell viability recovery.Since there is no effective method for mitochondria-related diseases up to now,the mitotherapy will provide a new approach for the prevention and treatment of these diseases.

关 键 词：细胞器移植 线粒体治疗 线粒体疾病 机制 线粒体 线粒体传递 

分 类 号：R-05[医药卫生] R329.24