改良的Mosher法测定高烯丙醇的绝对构型  

Modified Mosher's method for determination of absolute configuration of homoallylic alcohols

作　　者：杨皓然 杨新美 刘爱芹[1,2] TOMOYA Fujiwara[4] 姚庆强 刘波[1,2] YANG Haoran;YANG Xinmei;LIU Aiqin;TOMOYA Fujiwara;YAO Qingqiang;LIU Bo(hool of Medicine and Life Sciences,University of Jinan-Shandong Academy of Medical Sciences,Jinan 250200,Shandong,China;Institute of Materia Medica,Shandong Academy of Medical Sciences,Key Laboratory for Biotech-Drugs Ministry of Health, Key Laboratory of Rare and Uncommon Diseases of Shandong Province,Jinan 250062,Shandong,China;Department of Pharmacy,Shandong Provincial Qianfoshan hospital,Jinan 250014,Shandong,China;Graduate School of Medicine and Pharmaceutical Sciences,University of Toyama,Sugitani,Toyama 930-0194,Japan)

机构地区：[1]济南大学山东省医学科学院,医学与生命科学学院,山东济南250200 [2]山东省医学科学院药物研究所,国家卫生部生物技术药物重点实验室,山东省罕少见病重点实验室,山东济南250062 [3]山东大学附属千佛山医院药学部,山东济南250014 [4]Graduate School of Medicine and Pharmaceutical Sciences,University of Toyama,Sugitani,Toyama 930-0194,Japan

出　　处：《化学研究》2018年第2期152-159,共8页Chemical Research

基　　金：山东省自然科学基金(ZR2017PH003);山东省医学科学院院级科技计划(2016-5)

摘　　要：有机化合物绝对构型的测定在有机合成和药物合成方面都有着举足轻重的地位.Mosher法就是利用核磁共振波谱技术来确定复杂化合物绝对构型时所采用的一种巧妙方法.本研究即采用改良的Mosher法对无水鞘氨醇类天然产物pachastrissamine及其异构体全合成过程中的重要中间体高烯丙醇进行了绝对构型的测定.Determination of the absolute configuration of organic compounds in organic synthesis and drug synthesis has a pivotal position.Mosher s method provides a practical solution for the stereoche-mistry determination of complex products by means of NMR spectroscopy.In this study,the modified Mosher s method was used to determine the absolute configuration of homoallylic alcohols as the important intermediates for the synthesis of pachastrissamine and its isoforms.

关 键 词：Mosher法 高烯丙醇 绝对构型 结构测定 

分 类 号：R914.5[医药卫生—药物化学]