左旋多巴联合视觉刺激训练治疗青少年屈光不正性弱视  

Levodopa combined with visual stimulation training in the treatment of ametropic amblyopia in adolescents

作　　者：贺志华[1] 李炎[2] 张丽[3] Zhi-Hua He;Yan Li;Li Zhang(Department of Ophthalmology,Huanggang Center Hospital,Huanggang 438000,Hubei Province,China;Department of Clinical Laboratory,Huanggang Center Hospital,Huanggang 438000,Hubei Province,China;Department of Ophthalmology,Aier Eye Hospital(Huanggang),Huanggang 438000,Hubei Province,China)

机构地区：[1]中国湖北省黄冈市中心医院眼科,438000 [2]中国湖北省黄冈市中心医院检验科,438000 [3]黄冈爱尔眼科医院眼科,中国湖北省黄冈市438000

出　　处：《国际眼科杂志》2018年第6期1163-1165,共3页International Eye Science

摘　　要：目的:探讨应用左旋多巴和视觉刺激训练治疗青少年屈光不正性弱视的研究效果。方法:选取2013-05/2016-05在我院接受治疗的青少年屈光不正性弱视64例68眼进行本次研究,将其按数字表法随机分成观察组(32例33眼)与对照组(32例35眼)。对照组采取视觉刺激训练疗法,观察组在对照组的基础上给予左旋多巴治疗。24wk后比较两组的临床效果以及治疗前后P-VEP、视觉敏感度的变化。结果:治疗24wk结束后,观察组的总有效率(91%)明显高于对照组(71%),差异有统计学意义(P<0.05);虽然对照组的P-VEP P100波幅升高,潜伏期缩短,但观察组的效果更显著,差异有统计学意义(P<0.05)。结论:左旋多巴和视觉刺激训练联合治疗青少年屈光不正性弱视的效果显著,能够较好地纠正其视觉敏感度,改善视神经传导功能。AIM:To explore the effect of levodopa and visual stimulation training in the treatment of adolescent ametropic amblyopia.METHODS:Sixty-four adolescents(68 eyes)with ametropic amblyopia who treated in our hospital from May 2013 to May 2016 were included into this study,and the patients were randomly divided into the observation group(n=32,33 eyes)and the control group(n=32,35 eyes).The patients in the control group received visual stimulation training therapy,and the patients in the observation group were given levodopa on the basis of the control group.After treated for 24wk,the clinical effects and changes of P-VEP and visual sensitivity before and after treatment were compared.RESULTS:After treated for 24wk,the total effective rate of the observation group(91%)was significantly higher than that of the control group(71%),and the difference was statistically significant(P<0.05).Although the amplitude of P-VEP P100 in the control group increased and the latency was shortened,the effect of the observation group was more significant,and the difference was significant(P<0.05).CONCLUSIONS:Levodopa combined with visual stimulation training has significant effect in the treatment of adolescent ametropic amblyopia,it can better correct the visual sensitivity,and improve optic nerve conduction function.

关 键 词：屈光不正性弱视 左旋多巴 视觉刺激训练 青少年 

分 类 号：R777.44[医药卫生—眼科]