Research progress of polysaccharide nanocarriers based on traditional Chinese medicine Thallus japonica  

作　　者：Yue-Ming Yu Kai-Li Wang Bing-Jie Wang Lei Fang Meng-Na Liu Xin-Xin Fan Hong-Jie Mu Da-Quan Chen 

机构地区：[1]Pharmacology Department of Yantai University,Shandong University Collaborative Innovation Center,Yantai,China

出　　处：《TMR Cancer》2018年第3期82-86,共5页TMR肿瘤

摘　　要：In the last few years,the overall incidence of malignant tumors has been increasing in the country.In order to find effective anti-tumor drugs,the development and modification of natural drugs have become the focus of domestic and international researchers.Thallus japonica,composed of polysaccharides,minerals,amino acids,natural proteins,and lipids,is a traditional Chinese medicine with the functions of eliminating phlegm and disinhibiting water.At the same time,it has the edible and medicinal efficacy.There are a lot of active components that have been demonstrated to possess diverse biological activities including anti-tumor,anti-viral,anti-coagulant,and anti-bacterial,and so on in thallus japonica.Laminarin,composed of glucose,galactose,fucose and so on,is a common and high molecular weight heteropolysaccharide in brown algae(such as thallus japonica,kelp),and it is a potential anti-tumor drug.However,the lack of biological activity of natural polysaccharides limits the application of polysaccharides,so it is necessary to modify the structure or physical and chemical properties of it to enhance the anti-tumor activity of polysaccharides.In recent years,in order to improve the biological activity of laminarin,domestic and international researchers have introduced some groups on the surface of it.Moreover,use the function of modified groups to cause the changes in physicochemical property,spatial structure,substituent group and molecular weight to improve the anti-tumor activity in vitro and in vivo.Therefore,the structural modification has become the main and powerful means to improve the activity of polysaccharides.近年来,全国恶性肿瘤的整体发病率逐年提升,为寻找有效的抗肿瘤药物,天然药物的开发和改造成为国内外研究者研究的重点和热点。昆布,由多糖类、矿物质、氨基酸、天然蛋白、脂质等组成,是具有消痰,利水等功效的一种中药,同时具有食用和药用的双重价值。昆布中存在很多活性成分,这些成分已经被证明具有抗肿瘤、抗病毒、抗凝血以及抗菌等作用。其中,昆布多糖是一种在褐藻(如昆布,海带)中普遍存在的杂多糖,是抗肿瘤领域潜在的药物。但是,天然多糖的生物活性较低甚至是缺乏生物活性限制了多糖类化合物的应用,往往需对其结构或者理化性质进行改造,从而增强多糖类药物的活性。近年来,为提高昆布多糖的生物学活性,研究者多采用在其表面引入某种基团。利用修饰基团的功能引起多糖的理化性质、空间结构以及取代基和分子量的变化,从而达到提高多糖类的生物活性的目的。因此,结构修饰及改造已成为提高多糖类化合物活性的主要且有力的手段。

关 键 词：LAMINARIN Carrier ANTI-TUMOR Modification 

分 类 号：R[医药卫生]