Bioactive molecules in Siddha Polyherbal Nilavembu Kudineer alleviating symptoms of Dengue/Chikugunya  

作　　者：Rubeena Mattummal Divya Kallingilkalathil Gopi Sathiya Rajeshwaran Parameswaran Sunil Kumar Koppala Narayana 

机构地区：[1]Siddha Central Research Institute,Central Council for Research in Siddha,Ministry of AYUSH,Govt.of India,Arumbakkam,Chennai,India.

出　　处：《Traditional Medicine Research》2018年第5期215-229,共15页TMR传统医学研究

摘　　要：Dengue is the most prevalent arthropod-borne viral diseases in terms of morbidity and mortality in the recent decade with the classic symptoms of high fever,headache as well as muscle and joint pain.Nilavembu Kudineer(NK)is one among the 32 types of internal medicines described in the ancient Siddha system of medicine in south India which reduces fever and relieves body aches.NK,a polyherbal formulation made up of eight traditional herbs in equal parts,is also recommended for prevention and management of all types of viral infections including Dengue/Chikugunya.Exploration of bioactive compounds in the plants is the primary step for the standardization and bioactivity screening of plants and formulations.So the current study aims at recording the chemical constituents and medicinal activities of each ingredient of NK.The anti-pyretic,anti-inflammatory,analgesic and immunostimulant effects of NK have been attributed to more than one ingredient in NK.The medicinal property of the NK can be also attributed to the combined effect of all phytochemicals present in these eight herbs.The current study encompasses the various chemicals and the activities of individual herbs but a thorough stereoscopic and chromatographic investigation is required to trace out the major phytochemical entities which are retained once the NK is prepared by the traditional methods.就发病率和死亡率而言,登革热是近十年来最常见的节肢动物传播的病毒性疾病,以高热、头痛、肌肉和关节疼痛为典型症状。Nilavembu Kudineer(NK)是印度南部古代SIDDHA医学系统中记载的32种内科处方之一,它能退烧和缓解身体疼痛。NK是一种由8种传统草药组成的草药配方,被推荐用于预防和治疗各种类型的病毒感染,包括登革热/切昆贡亚热。生物活性成分的研究是药物及其制剂标准化和生物活性筛选的首要步骤。本研究旨在总结NK各成分的化学成分和药用活性。NK的解热、抗炎、镇痛和免疫刺激作用不仅归因于NK中的多种化学成分,也归因于这8种草药中所有化学成分的联合作用。目前的研究主要围绕单个药物的不同化学成分和活性物质,但需要进行彻底的立体和色谱研究,以追溯一旦采用传统的煎煮方法制备NK后保留的主要植物化学物质。

关 键 词：Anti-Dengue herbals Dengue virus Chikugunya Fever Pain FLAVIVIRUS 

分 类 号：R[医药卫生]