生化检测指标在急性胰腺炎诊断中的临床价值  

Clinical value of biochemical detection index in the diagnosis of acute pancreatitis

作　　者：许楠 XU Nan(Department of Clinical Laboratory,People忆s Hospital of Jilin City in Jilin Province,Jilin 132001,China)

机构地区：[1]吉林省吉林市人民医院检验科,吉林吉林132001

出　　处：《中国当代医药》2018年第30期125-127,共3页China Modern Medicine

摘　　要：目的探讨尿淀粉酶(U-Amy)、血淀粉酶(S-Amy)、胰脂肪酶(LPS)、胰蛋白酶原激活肽(TAP)以及C反应蛋白(CRP)等生化指标在急性胰腺炎(AP)诊断中的临床价值。方法选取2015年4月～2017年4月我院收治的196例胰腺炎患者作为研究对象,根据临床诊断分为AP组(n=91)和非AP组(n=105),其中AP组再分为轻症AP组(MAP组,n=57)和重症AP组(SAP组,n=34),另选取同期的40例健康体检者作为健康对照组。分别检测各组的U-Amy、S-Amy、LPS、TAP以及CRP等生化指标。结果健康对照组、非AP组、AP组的U-Amy、S-Amy以及TAP水平依次升高(P<0.05);AP组的LPS水平显著高于非AP组和健康对照组(P<0.05);AP组和非AP组两组患者的CRP水平均明显高于健康对照组(P<0.05)。SAP组的U-Amy、TAP和CRP水平明显高于MAP组(P<0.05),而两组间的S-Amy以及LPS水平比较差异无统计学意义(P>0.05)。早期AP诊断中,血清LPS检测的灵敏度和特异度分别为92.3%、91.4%,均明显高于其他四项指标。结论 U-AMY、S-AMY、LPS、TAP以及CRP指标均是诊断急性胰腺炎的良好的生化指标,LPS有助于提高早期诊断的准确性,而TAP和CRP则有助于判断病变严重程度以及评估治疗效果与预后。Objective To investigate the clinical value of biochemical indexes such as U-Amy,S-Amy,LPS,TAP and CRP in the diagnosis of acute pancreatitis(AP).Methods A total of 196 patients with pancreatitis admitted in our hospital from April 2015 to April 2017 were divided into the AP group(n=91)and the non-AP group(n=105)according to clinical diagnosis.Among them,the AP group was subdivided into the mild AP group(MAP,n=57)and the severe AP group(SAP,n=34).Another 40 healthy people at the same time were selected as the healthy control group.The biochemical indexes such as U-Amy,S-Amy,LPS,TAP and CRP were measured and analyzed in the each group respectively.Results The level of U-Amy,S-Amy and TAP in the healthy control group,the non-AP group and the AP group increased from low to high(P<0.05).The level of LPS in the AP group was significantly higher than that in the non-AP group and the healthy control group(P<0.05).The levels of CRP in the AP group and the non-AP group were significantly higher than those in the healthy control group(P<0.05).The level of U-Amy,TAP and CRP in the SAP group were significantly higher than those in the MAP group(P<0.05),while the differences in the S-Amy and LPS level between the two groups were not significant(P>0.05).In the diagnosis of early AP,the sensitivity and specificity of serum LPS detection were 92.3%and 91.4%,respectively,which were significantly higher than those of the other four indexes.Conclusion The indexes of U-Amy,S-Amy,LPS,TAP and CRP are good biochemical indexes for the diagnosis of AP.LPS can improve the accuracy of early diagnosis,while TAP and CRP help to judge the severity of the lesion and evaluate the therapeutic effect and prognosis.

关 键 词：淀粉酶 胰脂肪酶 C反应蛋白 急性胰腺炎 

分 类 号：R576[医药卫生—消化系统]