Esophageal metastasis of stem cell-subtype hepatocholangio carcinoma:Rare presentation of a rare tumor  

作　　者：Maeva Salimon Nicolas Chapelle Tamara Matysiak-Budnik Jean-Francois Mosnier Eric Frampas Yann Touchefeu 

机构地区：[1]Institut des Maladies de l’Appareil Digestif,Nantes University Hospital,Nantes 44000,France [2]Department of Pathology,Nantes University Hospital,Nantes 44000,France [3]Department of Radiology,Nantes University Hospital,Nantes 44000,France

出　　处：《World Journal of Gastroenterology》2018年第7期870-875,共6页世界胃肠病学杂志（英文版）

摘　　要：Hepatocholangiocarcinoma(c HCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma(HCC) and intrahepatic cholangiocarcinoma(ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable c HCC-ICC with stemcell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis. Histological and immunohistochemical analyses of biopsies from the esophageal lesion and the hepatic tumor confirmed the diagnosis of c HCC-ICC with a stem cell-subtype, according to the World HealthOrganization classification. After a multidisciplinary meeting, the patient was treated with chemotherapy. He received two cycles of a gemcitabine plus cisplatin regimen before bone progression, and he died 3 mo after the initial diagnosis.Hepatocholangiocarcinoma(c HCC-ICC) is a rare primary hepatic tumor defined by the presence of histological features of both hepatocellular carcinoma(HCC) and intrahepatic cholangiocarcinoma(ICC). Its prevalence ranges from 1%-5% of all primary liver cancers. We report the case of a 55-year-old cirrhotic male patient admitted to our university hospital for dysphagia, revealing a 10 cm lower-third esophageal metastasis of an unresectable c HCC-ICC with stemcell features. Computed tomography and abdominal magnetic resonance imaging scans revealed multiple hepatic lesions combining features of both HCC and ICC, associated with synchronous bone metastasis. Histological and immunohistochemical analyses of biopsies from the esophageal lesion and the hepatic tumor confirmed the diagnosis of c HCC-ICC with a stem cell-subtype, according to the World HealthOrganization classification. After a multidisciplinary meeting, the patient was treated with chemotherapy. He received two cycles of a gemcitabine plus cisplatin regimen before bone progression, and he died 3 mo after the initial diagnosis.

关 键 词：Hepatocholangiocarcinoma Stem cellsubtype ESOPHAGEAL METASTASIS CHEMOTHERAPY GEMCITABINE plus platinum-based CHEMOTHERAPY 

分 类 号：R57[医药卫生—消化系统]