Responsibility of hepatitis C virus in the development of hepatocellular carcinoma:From molecular alterations to possible solutions  

作　　者：Gaetano Bertino Giulia Malaguarnera Evelise Frazzetto Alice Sciuto Gaetano Inserra Guido Nicola Zanghì Michele Malaguarnera 

机构地区：[1]Hepatology Unit,Department of Clinical and Experimental Medicine,University of Catania,Policlinico“G.Rodolico”,Catania 95123,Italy [2]Research Center“the Great Senescence”,University of Catania,Catania 95100,Italy [3]Department of Biomedical and Biotechnological Science,University of Catania,Catania 95100,Italy [4]Department of Clinical and Experimental Medicine,University of Catania,Catania 95123,Italy [5]Department of Surgery,Policlinico Vittorio Emanuele University Hospital,University of Catania,Catania 95100,Italy

出　　处：《World Journal of Hepatology》2018年第6期448-451,共4页世界肝病学杂志（英文版）（电子版）

摘　　要：There are several causes of hepatocellular carcinoma(HCC), but certainly the hepatitis C virus(HCV) is one of the most common. The HCV is able to contribute, both directly and indirectly, to the development of HCC. Determining early HCV clearance before an advanced liver disease develops, is absolutely necessary as this prevents the initiation of the cascade of events induced by HCV that may result in the development of HCC. The early treatment of the infection and the clearance of HCV represents today, in the age of the direct antiviral agents(DAAs), an extraordinary opportunity for true prevention of the development of HCV-related HCC.There are several causes of hepatocellular carcinoma(HCC), but certainly the hepatitis C virus(HCV) is one of the most common. The HCV is able to contribute, both directly and indirectly, to the development of HCC. Determining early HCV clearance before an advanced liver disease develops, is absolutely necessary as this prevents the initiation of the cascade of events induced by HCV that may result in the development of HCC. The early treatment of the infection and the clearance of HCV represents today, in the age of the direct antiviral agents(DAAs), an extraordinary opportunity for true prevention of the development of HCV-related HCC.

关 键 词：Hepatitis C virus Hepatocellular carcinoma Inflammation FIBROSIS INSULIN-RESISTANCE Oxidative stress Direct ACTING ANTIVIRALS 

分 类 号：R[医药卫生]