Retinoic acid receptor beta promoter methylation and risk of cervical cancer  

作　　者：Chaninya Wongwarangkana Nasamon Wanlapakorn Jira Chansaenroj Yong Poovorawan 

机构地区：[1]Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University

出　　处：《World Journal of Virology》2018年第1期1-9,共9页世界病毒学杂志

基　　金：Supported by Research Chair Grant from the National Science and Technology Development Agency,No.P-15-50004;the Center of Excellence in Clinical Virology,Chulalongkorn Unversity and King Chulalongkourn Memorial Hospital,No.GCE 5900930-005;the Rachadapisek Sompote Fund of Chulalongkorn University for postdoctoral fellowships to Chaninya Wongwarangkana

摘　　要：Cervical cancer is one of the leading causes of death in women worldwide, particularly in developing countries. Human papillomavirus has been reported as one of the key etiologic factors in cervical carcinoma. Likewise, epigenetic aberrations have ability to regulate cancer pathogenesis and progression. Recent research suggested that methylation has been detected already at precancerous stages, which methylation markers may have significant value in cervical cancer screening. The retinoic acid receptor beta (RARβ) gene, a potential tumor suppressor gene, is usually expressed in normal epithelial tissue. Methylation of CpG islands in the promoter region of the RARβ gene has been found to be associated with the development of cervical cancer. To investigate whether RARβ methylation is a potential biomarker that predicts the progression of invasive cancer, we reviewed 14 previously published articles related to RARβ methylation. The majority of them demonstrated that the frequency of RARβ promoter methylation was significantly correlated with the severity of cervical epithelium abnormalities. However, methylation of a single gene may not represent the best approach for predicting disease prognosis. Analyzing combinations of aberrant methylation of multiple genes may increase the sensitivity, and thus this approach may serve as a better tool for predicting disease prognosis.Cervical cancer is one of the leading causes of death in women worldwide, particularly in developing countries. Human papillomavirus has been reported as one of the key etiologic factors in cervical carcinoma. Likewise, epigenetic aberrations have ability to regulate cancer pathogenesis and progression. Recent research suggested that methylation has been detected already at precancerous stages, which methylation markers may have significant value in cervical cancer screening. The retinoic acid receptor beta (RARβ) gene, a potential tumor suppressor gene, is usually expressed in normal epithelial tissue. Methylation of CpG islands in the promoter region of the RARβ gene has been found to be associated with the development of cervical cancer. To investigate whether RARβ methylation is a potential biomarker that predicts the progression of invasive cancer, we reviewed 14 previously published articles related to RARβ methylation. The majority of them demonstrated that the frequency of RARβ promoter methylation was significantly correlated with the severity of cervical epithelium abnormalities. However, methylation of a single gene may not represent the best approach for predicting disease prognosis. Analyzing combinations of aberrant methylation of multiple genes may increase the sensitivity, and thus this approach may serve as a better tool for predicting disease prognosis.

关 键 词：METHYLATION Cervical cancer RETINOIC acid receptor BETA Human PAPILLOMAVIRUS RISK correlation Promoter 

分 类 号：R[医药卫生]