Systemic lupus erythematosus complicated by noncirrhotic portal hypertension: A case report and review of literature  

作　　者：Qi-Bin Yang Yong-Long He Chun-Mei Peng Yu-Feng Qing Qi He Jing-Guo Zhou 

机构地区：[1]Department of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College [2]Clinical Medical School, Chengdu University of Traditional Chinese Medicine [3]Department of Rheumatology and Immunology, The First Affiliated Hospital of Chengdu Medical College

出　　处：《World Journal of Clinical Cases》2018年第13期688-693,共6页世界临床病例杂志

基　　金：Supported by the National Natural Science Foundation of China,No.81670801;Medical Association of Sichuan Province,No.S16027;Health and Family Planning Commission of Sichuan Province,No.17PJ059;Science and Technology Department of Sichuan Province,No.2018JY0498

摘　　要：A 48 year-old Chinese woman suffering from polyarthritis,irregular fever and trichomadesis was admitted to the hospital.A diagnosis of systemic lupus erythematosus(SLE)was made based on polyarthritis,pancytopenia,reduced complement 3,multiple positive autoantibodies,a positive Coomb’s test and protein in her urine.In addition,splenomegaly was detected during physical examination and confirmed by abdominal ultrasonography and magnetic resonance imaging,indicating that the patient had SLE and portal hypertension.Further negative investigations ruled out the possibility of cirrhosis.The patient was diagnosed with active SLE complicated by noncirrhotic portal hypertension(NCPH)without liver histopathology,due to the patient’s refusal for liver biopsy.Portal vein diameter and splenomegaly decreased following treatment with methylprednisolone,hydroxychloroquine and metoprolol tartrate.To date,SLE complicated by NCPH has rarely been reported,as it is under-recognized clinically as well as pathologically.Here we describe a case of SLE complicated by NCPH and review the literature for its characteristics,which may contribute to improving the recognition of NCPH and reducing missed and delayed diagnosis of this disorder.A 48 year-old Chinese woman suffering from polyarthritis,irregular fever and trichomadesis was admitted to the hospital.A diagnosis of systemic lupus erythematosus(SLE)was made based on polyarthritis,pancytopenia,reduced complement 3,multiple positive autoantibodies,a positive Coomb’s test and protein in her urine.In addition,splenomegaly was detected during physical examination and confirmed by abdominal ultrasonography and magnetic resonance imaging,indicating that the patient had SLE and portal hypertension.Further negative investigations ruled out the possibility of cirrhosis.The patient was diagnosed with active SLE complicated by noncirrhotic portal hypertension(NCPH)without liver histopathology,due to the patient’s refusal for liver biopsy.Portal vein diameter and splenomegaly decreased following treatment with methylprednisolone,hydroxychloroquine and metoprolol tartrate.To date,SLE complicated by NCPH has rarely been reported,as it is under-recognized clinically as well as pathologically.Here we describe a case of SLE complicated by NCPH and review the literature for its characteristics,which may contribute to improving the recognition of NCPH and reducing missed and delayed diagnosis of this disorder.

关 键 词：Noncirrhotic PORTAL HYPERTENSION SYSTEMIC LUPUS ERYTHEMATOSUS Clinical presentation Diagnosis 

分 类 号：R[医药卫生]