Mystery behind labial and oral melanotic macules: Clinical, dermoscopic and pathological aspects of Laugier-Hunziker syndrome  

作　　者：Ning Duan Yang-Heng Zhang Wen-Mei Wang Xiang Wang 

机构地区：[1]Department of Oral Medicine, Nanjing Stomatological Hospital, Medical School of Nanjing University [2]Department of Periodontology, Nanjing Stomatological Hospital, Medical School of Nanjing University

出　　处：《World Journal of Clinical Cases》2018年第10期322-334,共13页世界临床病例杂志

基　　金：Supported by The National Natural Scientific Foundation of China,No.81570978;the Nonprofit Industry Research Specific Fund of National Health and Family Planning Commission of China,No.201502018;the Key Project of Science and Technology Department of Jiangsu Province,No.BL2014018;the Project of Invigorating Health Care through Science,Technology and Education:the Project of Jiangsu Provincial Medical Youth Talent,No.QNRC2016118

摘　　要：Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome(LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. The important differential diagnoses of mucocutaneous and nail pigmentation are provided. An accurate diagnosis is crucial to design a reasonable medical strategy, including management options, malignant transformation surveillance, and psychological support. It is important that clinicians conduct long-term follow-up and surveillance due to the potential risks of malignant transformation and local severe complications in some conditions.Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome(LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. The important differential diagnoses of mucocutaneous and nail pigmentation are provided. An accurate diagnosis is crucial to design a reasonable medical strategy, including management options, malignant transformation surveillance, and psychological support. It is important that clinicians conduct long-term follow-up and surveillance due to the potential risks of malignant transformation and local severe complications in some conditions.

关 键 词：Laugier-Hunziker SYNDROME DERMOSCOPY Pathology PIGMENTATION Differential diagnosis PEUTZ-JEGHERS SYNDROME NEUROFIBROMATOSIS type 1 Carney complex Melanonychia 

分 类 号：R[医药卫生]