Vitamin C in the critically ill-indications and controversies  

作　　者：Christoph S Nabzdyk Edward A Bittner 

机构地区：[1]Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School

出　　处：《World Journal of Critical Care Medicine》2018年第5期52-61,共10页世界重症医学杂志

摘　　要：Ascorbic acid(vitamin C) elicits pleiotropic effects in thebody. Among its functions, it serves as a potent antioxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that highdose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential.Ascorbic acid(vitamin C) elicits pleiotropic effects in thebody. Among its functions, it serves as a potent antioxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that highdose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect to its therapeutic potential.

关 键 词：Ascorbic acid VITAMIN C SEPSIS Shock Critical care medicine VASOPRESSORS CARDIOVASCULAR 

分 类 号：R[医药卫生]