腹腔灌注化疗药物联合薏苡仁油注射液治疗恶性腹腔积液的临床效果观察  

Analysis on Clinical Effect of Intraperitoneal Perfusion Chemotherapy Drugs and Coicis Semen Oil Injection in the Treatment of Malignant Peritoneal Effusion

作　　者：卢立欣 刘学红 LU Lixin;LIU Xuehong(Shandong Provincial Third Hospital,Jinan,250031)

机构地区：[1]山东省立第三医院,250031

出　　处：《实用癌症杂志》2018年第11期1819-1822,共4页The Practical Journal of Cancer

摘　　要：目的观察腹腔灌注化疗药物联合薏苡仁油注射液治疗恶性腹腔积液的临床效果和安全性。方法收集诊断为恶性肿瘤并发恶性腹腔积液的患者56例,按照随机数字表法分为观察组和对照组,各28例。观察组采用腹腔灌注化疗药物联合薏苡仁油注射液治疗,对照组采用单纯腹腔灌注化疗药物治疗,比较两组患者治疗前后主要中医证候积分的变化,以及临床疗效和不良反应的差异。结果观察组治疗后主要中医证候积分均较治疗前显著下降(P <0. 05,P <0. 01),对照组腹痛、腹胀、神疲积分较治疗前显著下降(P <0. 01),但纳差和面色积分与治疗前差异无统计学意义(P> 0. 05),观察组治疗后各证候积分均显著低于对照组(P <0. 05)。观察组临床有效率为71. 4%,显著高于对照组的42. 9%,差异有统计学意义(P <0. 05)。两组患者恶心呕吐、骨髓抑制、肝功能损害和肾功能损害发生率比较,差异均无统计学意义(P> 0. 05)。结论腹腔灌注化疗药物联合薏苡仁油注射液治疗恶性腹腔积液的临床效果显著,安全性好,推荐在临床上应用。Objective To observe the clinical curative effect of intraperitoneal perfusion chemotherapy drugs and coicis semen oil injection in the treatment of malignant peritoneal effusion.Methods 56 patients with malignant tumor and malignant peritoneal effusion were divided into the observation group(n=28)and the control group(n=28)according to the random number table method.The observation group received intraperitoneal chemotherapy drugs and coicis semen injection,while the control group received intraperitoneal perfusion chemotherapy drugs only.The traditional Chinese medicine symptoms score before and after treatment,clinical effect and incidences of adverse reactions between the 2 groups were observed.Results The scores in the observation group after treatment were all obviously lower than before treatment(P<0.05,P<0.01).The scores of abdominal pain,abdominal distension and lassitude after treatment in the control group were obviously lower than before treatment(P<0.01),while the differences of the scores of poor appetite and complexion in the control group before and after treatment had no statistical significance(P>0.05).The scores of all symptoms in the observation group after treatment were obviously lower than the control group(P<0.05).The clinical efficacy rate in the observation group(71.4%)was obviously higher than the control group(42.9%)(P<0.05).The differences of incidences of nausea and vomiting,myelosuppression,liver and renal damage between the 2 groups had no statistical significance(P>0.05).Conclusion The clinical curative effect and security of intraperitoneal perfusion chemotherapy drugs and coicis semen oil injection in the treatment of malignant peritoneal effusion is significant,therefore it could be recommended in clinical application.

关 键 词：薏苡仁 恶性腹腔积液 腹腔内化疗 

分 类 号：R73-36[医药卫生—肿瘤]