Ultraviolet-induced alloantigen-specific immunosuppression in transplant immunity  

作　　者：Tomohide Hori Kagemasa Kuribayashi Kanako Saito Linan Wang Mie Torii Shinji Uemoto Taku Iida Shintaro Yagi Takuma Kato 

机构地区：[1]Department of Hepato-Pancreato-Biliary and Transplant Surgery, Kyoto University Graduate School of Medicine,Kyoto 606-8507, Japan [2]Department of Cellular and Molecular Immunology, Mie University Graduate School of Medicine,Tsu 514-8507, Japan [3]Department of Hematology and Medical Oncology, Mie University Graduate School of Medicine,Tsu 514-8507, Japan

出　　处：《World Journal of Transplantation》2015年第1期11-18,共8页世界移植杂志

摘　　要：After the first observation of the immunosuppressive effects of ultraviolet(UV) irradiation was reported in 1974, therapeutic modification of immune responses by UV irradiation began to be investigated in the context immunization. UV-induced immunosuppression is via the action of regulatory T cells(Tregs). Antigen-specific Tregs were induced by high-dose UV-B irradiation before antigen immunization in many studies, as it was considered that functional alteration and/or modulation of antigen-presenting cells by UV irradiation was required for the induction of antigen-specific immunosuppression. However, it is also reported that UV irradiation after immunization induces antigen-specific Tregs. UV-induced Tregs are also dominantly transferable, with interleukin-10 being important for UV-induced immunosuppression. Currently, various possible mechanisms involving Treg phenotype and cytokine profile have been suggested. UV irradiation accompanied by alloantigen immunization induces alloantigen-specific transferable Tregs, which have potential therapeutic applications in the transplantation field. Here we review the current status of UV-induced antigen-specific immunosuppression on the 40th anniversary of its discovery.After the first observation of the immunosuppressive effects of ultraviolet(UV) irradiation was reported in 1974, therapeutic modification of immune responses by UV irradiation began to be investigated in the context immunization. UV-induced immunosuppression is via the action of regulatory T cells(Tregs). Antigen-specific Tregs were induced by high-dose UV-B irradiation before antigen immunization in many studies, as it was considered that functional alteration and/or modulation of antigen-presenting cells by UV irradiation was required for the induction of antigen-specific immunosuppression. However, it is also reported that UV irradiation after immunization induces antigen-specific Tregs. UV-induced Tregs are also dominantly transferable, with interleukin-10 being important for UV-induced immunosuppression. Currently, various possible mechanisms involving Treg phenotype and cytokine profile have been suggested. UV irradiation accompanied by alloantigen immunization induces alloantigen-specific transferable Tregs, which have potential therapeutic applications in the transplantation field. Here we review the current status of UV-induced antigen-specific immunosuppression on the 40th anniversary of its discovery.

关 键 词：ALLOANTIGEN ULTRAVIOLET irradiation Donorspecific IMMUNOSUPPRESSION INTERLEUKIN-10 REGULATORY T cells 

分 类 号：R[医药卫生]