Regulation of Wnt/β-catenin signaling by herpesviruses  

作　　者：Kevin J Zwezdaryk Joseph A Combs Cindy A Morris Deborah E Sullivan 

机构地区：[1]Department of Microbiology and Immu-nology, Tulane University School of Medicine

出　　处：《World Journal of Virology》2016年第4期144-154,共11页世界病毒学杂志

摘　　要：The Wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. It is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. Successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. Many herpesviruses establish latency in progenitor cells and viral reactivation is linked to host-cell proliferation and differentiation status. Importantly, Wnt/β-catenin is tightly connected to stem/progenitor cell maintenance and differentiation. Numerous studies have linked Wnt/β-catenin signaling to a variety of cancers, emphasizing the importance of Wnt/β-catenin pathways in development, tissue homeostasis and disease. This review details how the alpha-, beta-, and gammaherpesviruses interact and manipulate the Wnt/β-catenin pathway to promote a virus-centric agenda.The Wnt/β-catenin signaling pathway is instrumental in successful differentiation and proliferation of mammalian cells. It is therefore not surprising that the herpesvirus family has developed mechanisms to interact with and manipulate this pathway. Successful coexistence with the host requires that herpesviruses establish a lifelong infection that includes periods of latency and reactivation or persistence. Many herpesviruses establish latency in progenitor cells and viral reactivation is linked to host-cell proliferation and differentiation status. Importantly, Wnt/β-catenin is tightly connected to stem/progenitor cell maintenance and differentiation. Numerous studies have linked Wnt/β-catenin signaling to a variety of cancers, emphasizing the importance of Wnt/β-catenin pathways in development, tissue homeostasis and disease. This review details how the alpha-, beta-, and gammaherpesviruses interact and manipulate the Wnt/β-catenin pathway to promote a virus-centric agenda.

关 键 词：HERPESVIRUS Herpes simplex virus-1 VARICELLA zoster VIRUS Cytomegalovirus Epstein-Barr VIRUS Kaposi’s sarcoma-associated HERPESVIRUS WNT/Β-CATENIN Glycogen synthase kinase-3 AXIN 

分 类 号：R282.71[医药卫生—中药学]