Acute hepatitis after amiodarone infusion  

作　　者：Paulo Fonseca Adelaide Dias Helena Gonçalves Aníbal Albuquerque Vasco Gama 

机构地区：[1]Cardiology Department,Gaia Hospital Center,4434-502 Vila Nova de Gaia,Portugal

出　　处：《World Journal of Clinical Cases》2015年第10期900-903,共4页世界临床病例杂志

摘　　要：Acute hepatitis is a very rare, but potentially fatal, adverse effect of intravenous amiodarone. We present a case of an 88-year-old man with history of ischemic dilated cardiomyopathy and severely depressed left ventricular function that was admitted to our coronary care unit with diagnosis of decompensated heart failure and non-sustained ventricular tachycardia. A few hours after the beginning of intravenous amiodarone he developed an acute hepatitis. There was a completely recovery within the next days after amiodarone withdrawn and other causes of acute hepatitis have been ruled out. This case highlights the need for close monitoring of hepatic function during amiodarone infusion in order to identify any potential hepatotoxicity and prevent a fatal outcome. Oral amiodarone is, apparently, a safe option in these patients.Acute hepatitis is a very rare, but potentially fatal, adverse effect of intravenous amiodarone. We present a case of an 88-year-old man with history of ischemic dilated cardiomyopathy and severely depressed left ventricular function that was admitted to our coronary care unit with diagnosis of decompensated heart failure and non-sustained ventricular tachycardia. A few hours after the beginning of intravenous amiodarone he developed an acute hepatitis. There was a completely recovery within the next days after amiodarone withdrawn and other causes of acute hepatitis have been ruled out. This case highlights the need for close monitoring of hepatic function during amiodarone infusion in order to identify any potential hepatotoxicity and prevent a fatal outcome. Oral amiodarone is, apparently, a safe option in these patients.

关 键 词：Polysorbate 80 HEPATITIS HEPATOTOXICITY Idiosyncratic reactions AMIODARONE 

分 类 号：R575.1[医药卫生—消化系统]