Increasing access to kidney transplantation for sensitized recipient through three-way kidney paired donation with desensitization: The first Indian report  

作　　者：Vivek B Kute Himanshu V Patel Pankaj R Shah Pranjal R Modi Veena R Shah Sayyed J Rizvi Bipin C Pal Manisha P Modi Priya S Shah Umesh T Varyani Pavan S Wakhare Saiprasad G Shinde Viajay A Ghodela Minaxi H Patel Varsha B Trivedi Hargovind L Trivedi 

机构地区：[1]Department of Nephrology and Clinical Transplantation,Institute of Kidney Diseases and Research Center,Dr.HL Trivedi Institute of Transplantation Sciences(IKDRC-ITS) [2]Department of Urology and Transplantation,IKDRC-ITS [3]Department of Anesthesia,IKDRC-ITS [4]Department of Pathology,Laboratory Medicine,Transfusion Services and Immunohematology,IKDRC-ITS

出　　处：《World Journal of Clinical Cases》2016年第10期351-355,共5页世界临床病例杂志

摘　　要：The combination of kidney paired donation(KPD) with desensitization represents a promising method of increasing the rate of living donor kidney transplantation(LDKT) in immunologically challenging patients. Patients who are difficult to match and desensitize due to strong donor specific antibody are may be transplanted by a combination of desensitization and KPD protocol with more immunologically favorable donor. We present our experience of combination of desensitization protocol with three-way KPD which contributed to successful LDKT in highly sensitized end stage renal disease patient. All recipients were discharged with normal and stable allograft function at 24 mo follow up. We believe that this is first report from India where three-way KPD exchange was performed with the combination of KPD and desensitization. The combination of desensitization protocol with KPD improves access and outcomes of LDKT.The combination of kidney paired donation(KPD) with desensitization represents a promising method of increasing the rate of living donor kidney transplantation(LDKT) in immunologically challenging patients. Patients who are difficult to match and desensitize due to strong donor specific antibody are may be transplanted by a combination of desensitization and KPD protocol with more immunologically favorable donor. We present our experience of combination of desensitization protocol with three-way KPD which contributed to successful LDKT in highly sensitized end stage renal disease patient. All recipients were discharged with normal and stable allograft function at 24 mo follow up. We believe that this is first report from India where three-way KPD exchange was performed with the combination of KPD and desensitization. The combination of desensitization protocol with KPD improves access and outcomes of LDKT.

关 键 词：KIDNEY failure Chronic DESENSITIZATION IMMUNOLOGIC KIDNEY transplantation Blood group INCOMPATIBILITY Living donors Tissue and organ procurement 

分 类 号：R699.2[医药卫生—泌尿科学]