supported by the Natural Science Foundation of China(Nos.82203178,82272852,and 82103687);Jiangsu Provincial Key Research and Development Program(No.BE2020619);Natural Science Foundation of Jiangsu Province(No.BK20220191);Nanjing Medical Science and Technology Development Foundation(No.YKK22086).
To the Editor:Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract.GISTs mostly occur in the stomach or small intestine among patients around 40-60 years of age,an...
supported by the National Natural Science Foundation of China (Grant No. 81973861);Zhejiang Provincial Ministry Medical and Health Co-construction Major Project (Grant No. 20214355173);Zhejiang Science and Technology Department“Vanguard”“Leading Goose”research (Grant No. 2023C03044);Zhejiang Provincial Health“Leading Talents”Project;Zhejiang Medical and Health Science and Technology Project (Grant No. 2022KY558)。
Angiogenesis is considered a hallmark pathophysiological process in tumor development. Aberrant vasculature resulting from tumor angiogenesis plays a critical role in the development of resistance to breast cancer tre...
supported by the National Natural Science Foundation of China(No.81960100,81760511).
Colorectal cancer(CRC)is one of the most common cancers around the world,and it is one of the leading causes of cancer-related death.1 Although anti-EGFR therapy and immune checkpoint inhibitor(ICl)therapy are becomin...
supported by National Science and Technology Major Project of China (2019YFC1605002);National Natural Science Foundation of China (31872886)。
Mango(Mangifera indica L.)is a tropical fruit that is widely consumed as both fresh fruits and processed products around the world.The high incidence of mango allergy,on the other hand,has sparked widespread concern.T...
Tumors can be classified into distinct immunophenotypes based on the presence and arrangement of cytotoxic immune cells within the tumor microenvironment(TME).Hot tumors,characterized by heightened immune activity and...
National Natural Science Foundation of China and by the Beijing Sci-Tech Program(No.Z191100006619114);Natural Science Foundation of China(No.81701607);Peking University People’s Hospital Scientific Research Development Funds(No.RDZH2022-03)
To the Editor:Primary Sjögren’s syndrome(pSS)is a multi-systemic autoimmune disease characterized by the exocrine gland(mainly salivary and lacrimal glands)involvement,leading to xerostomia and xerophthalmia.[1]The c...
supported by the National Natural Science Foundation of China(82172094);Funds of Sichuan Province for Distinguished Young Scholar(2021JDJQ0037,China)。
Radiotherapy(RT) can potentially induce systemic immune responses by initiating immunogenic cell death(ICD) of tumor cells.However,RT-induced antitumor immunologic responses are sporadic and insufficient against cance...
Supported by National Natural Science Foundation of China:Mechanism study of Xijiao Dihuang combined Prescription in Treating Immune Thrombocytopenia Based on PD-1/PD-L1 Regulating Teff/Treg Immune Balance(No.8200152588);National Natural Science Foundation of China:Study on the mechanism of Yiqi Yangyin Qingre Huayu Recipe regulation of ITP platelet destruction and production through the imbalance of Th17/Treg and Notch pathway(No.81373847).
Background:To explore the role and mechanism of T cell imbalance in the process of immune thrombocytopenic purpura(ITP)and the efficacy of the Ningxue Shengban decoction in treating this disease.Methods:Passive immune...
funded by National Natural Science Foundation of China(82171814).
Pickering emulsions were prepared by phacoemulsification in an ice water bath with squalene as the oil phase and an aluminum adjuvant as the particle stabilizer.The effects of formulation and process conditions on the...
This work was supported by the National Natural Science Foundation of China(Grant Nos.52072210 and 52111530230);Key R&D Projects of Social Development of Hainan Provincial Department of Science and Technology(Grant No.ZDYF2020137);Tsinghua University Beijing Union Medical CollegeeHospital Cooperation Project(Grant No.20191080871).
The disruption and reconstruction of the TREM2^(+) tissue resident macrophage(TRM)barrier on the surface of synovial lining play a key role in the activation and"remission"of rheumatoid arthritis(RA),which engender th...