IMMUNOLOGIC

作品数:78被引量:290H指数:7
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相关领域:医药卫生更多>>
相关作者:张罗韩德民王成硕王学艳戴敏更多>>
相关机构:首都医科大学浙江大学安徽医科大学第四军医大学唐都医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划安徽省自然科学基金更多>>
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Exploration of the immunologic characteristics of KIT/PDGFRA wild-type gastrointestinal stromal tumor and potential application of neoantigen vaccination
《Chinese Medical Journal》2024年第21期2627-2629,共3页Yishan Li Qin Wang Lin Li Shaohua Yuan Hui Chen Rutian Li Fangcen Liu 
supported by the Natural Science Foundation of China(Nos.82203178,82272852,and 82103687);Jiangsu Provincial Key Research and Development Program(No.BE2020619);Natural Science Foundation of Jiangsu Province(No.BK20220191);Nanjing Medical Science and Technology Development Foundation(No.YKK22086).
To the Editor:Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract.GISTs mostly occur in the stomach or small intestine among patients around 40-60 years of age,an...
关键词:gastrointestinal STOMACH INTESTINE 
Research progress in tumor angiogenesis and drug resistance in breast cancer被引量:1
《Cancer Biology & Medicine》2024年第7期571-585,共15页Jiancheng Mou Chenhong Li Qinghui Zheng Xuli Meng Hongchao Tang 
supported by the National Natural Science Foundation of China (Grant No. 81973861);Zhejiang Provincial Ministry Medical and Health Co-construction Major Project (Grant No. 20214355173);Zhejiang Science and Technology Department“Vanguard”“Leading Goose”research (Grant No. 2023C03044);Zhejiang Provincial Health“Leading Talents”Project;Zhejiang Medical and Health Science and Technology Project (Grant No. 2022KY558)。
Angiogenesis is considered a hallmark pathophysiological process in tumor development. Aberrant vasculature resulting from tumor angiogenesis plays a critical role in the development of resistance to breast cancer tre...
关键词:ANGIOGENESIS breast cancer CHEMOTHERAPY drug resistance vascular normalization immunologic therapy tumor microenvironment(TME) 
Genetic and immunologic characteristics of colorectal cancer patients with KRAS mutations and predictive significance of tumor immune microenvironment in adjuvant chemotherapy
《Genes & Diseases》2024年第3期43-46,共4页Zhengqi Wen Wenliang Li Chengmin Shi Junrui Ma Sihui Zhao Ruize Zhou Xihong Liu Rong Yang Zhiping Zhang Hushan Zhang Bo Li 
supported by the National Natural Science Foundation of China(No.81960100,81760511).
Colorectal cancer(CRC)is one of the most common cancers around the world,and it is one of the leading causes of cancer-related death.1 Although anti-EGFR therapy and immune checkpoint inhibitor(ICl)therapy are becomin...
关键词:KRAS COLORECTAL patients 
Recent advances in the study of epitopes,allergens and immunologic cross-reactivity of edible mango
《Food Science and Human Wellness》2024年第3期1186-1194,共9页Honglei Guo Yanjun Cong 
supported by National Science and Technology Major Project of China (2019YFC1605002);National Natural Science Foundation of China (31872886)。
Mango(Mangifera indica L.)is a tropical fruit that is widely consumed as both fresh fruits and processed products around the world.The high incidence of mango allergy,on the other hand,has sparked widespread concern.T...
关键词:MANGO ALLERGEN EPITOPE Immunocross-reactivity Prospects 
Immunologic tumor microenvironment modulators for turning cold tumors hot被引量:3
《Cancer Communications》2024年第5期521-553,共33页Gholam-Reza Khosravi Samaneh Mostafavi Sanaz Bastan Narges Ebrahimi Roya Safari Gharibvand Nahid Eskandari 
Tumors can be classified into distinct immunophenotypes based on the presence and arrangement of cytotoxic immune cells within the tumor microenvironment(TME).Hot tumors,characterized by heightened immune activity and...
关键词:cold tumor hot tumor immunologic modulator IMMUNOTHERAPY therapeutic strategy tumor microenvironment 
Immunologic characteristics and predictive risk factors of primary Sjögren’s syndrome complicated with malignant lymphoma:A multicenter case-control study
《Chinese Medical Journal》2024年第10期1252-1254,共3页Yuebo Jin Linqing Hou Hao Li Liyun Zhang Yuanhong Peng Naidi Wang Jing He 
National Natural Science Foundation of China and by the Beijing Sci-Tech Program(No.Z191100006619114);Natural Science Foundation of China(No.81701607);Peking University People’s Hospital Scientific Research Development Funds(No.RDZH2022-03)
To the Editor:Primary Sjögren’s syndrome(pSS)is a multi-systemic autoimmune disease characterized by the exocrine gland(mainly salivary and lacrimal glands)involvement,leading to xerostomia and xerophthalmia.[1]The c...
关键词:mortality LYMPHOMA MALIGNANT 
Self-sufficient nanoparticles with dual-enzyme activity trigger radical storms and activate cascade-amplified antitumor immunologic responses
《Acta Pharmaceutica Sinica B》2024年第2期821-835,共15页Liping Bai Jin Yang Siting Yu Zhongzheng Xiang Yuanyuan Zeng Meiling Shen Xiaorong Kou Qinjie Wu Changyang Gong 
supported by the National Natural Science Foundation of China(82172094);Funds of Sichuan Province for Distinguished Young Scholar(2021JDJQ0037,China)。
Radiotherapy(RT) can potentially induce systemic immune responses by initiating immunogenic cell death(ICD) of tumor cells.However,RT-induced antitumor immunologic responses are sporadic and insufficient against cance...
关键词:Dual-enzyme activity Radiotherapy Chemodynamic therapy Fenton-likereaction Radical storms Immunogeniccell death Tumormicroenvironment Systemicimmunity 
Mechanism study of the effect of Ningxue Shengban decoction on regulating the ratio of Treg/Th17 cells and downstream inflammatory factors in immune thrombocytopenia model mice
《Integrative Medicine Discovery》2023年第36期1-7,共7页Ai-Di Wang Hong-Lei Guo Dong-Jie Xie Xiang-Yu Zuo Lin Ma Bao-Shan Liu 
Supported by National Natural Science Foundation of China:Mechanism study of Xijiao Dihuang combined Prescription in Treating Immune Thrombocytopenia Based on PD-1/PD-L1 Regulating Teff/Treg Immune Balance(No.8200152588);National Natural Science Foundation of China:Study on the mechanism of Yiqi Yangyin Qingre Huayu Recipe regulation of ITP platelet destruction and production through the imbalance of Th17/Treg and Notch pathway(No.81373847).
Background:To explore the role and mechanism of T cell imbalance in the process of immune thrombocytopenic purpura(ITP)and the efficacy of the Ningxue Shengban decoction in treating this disease.Methods:Passive immune...
关键词:immune thrombocytopenic purpura immunologic balance traditional Chinese medicine Ningxue Shengban decoction 
The effect of Pickering emulsion adjuvants on the immune efficacy of the COVID-19 polypeptide vaccine
《ChemPhysMater》2023年第3期259-266,共8页Zhuanqing Huang Qi Sun Haoyuan Shi Sen Yang Yuanyuan Li Yue Ma Fei Yang Zhenwei Shi Yalong Yang Ying Zhang Hui Gong Fenghua Xu 
funded by National Natural Science Foundation of China(82171814).
Pickering emulsions were prepared by phacoemulsification in an ice water bath with squalene as the oil phase and an aluminum adjuvant as the particle stabilizer.The effects of formulation and process conditions on the...
关键词:Pickering emulsions Ultrasonic emulsification Immunologic adjuvant COVID-19 Polypeptide vaccine 
Ultrasound-driven BaTiO_(3) nanorobots patching immunologic barrier to cure chronic rheumatoid arthritis被引量:1
《Journal of Advanced Ceramics》2023年第5期1105-1117,共13页Le Jiang Yifan Wang Chunlin Liu Nan Xu Wenshuo Li Lei Wang Yixian Wu Jingyun Wang Zhijun He Fengbo Sun Lingyun Zhao Qiong Wu Xiumei Wang Huihui Yuan Xiaohui Wang Xiaodan Sun 
This work was supported by the National Natural Science Foundation of China(Grant Nos.52072210 and 52111530230);Key R&D Projects of Social Development of Hainan Provincial Department of Science and Technology(Grant No.ZDYF2020137);Tsinghua University Beijing Union Medical CollegeeHospital Cooperation Project(Grant No.20191080871).
The disruption and reconstruction of the TREM2^(+) tissue resident macrophage(TRM)barrier on the surface of synovial lining play a key role in the activation and"remission"of rheumatoid arthritis(RA),which engender th...
关键词:ultrasound-driven BaTiO_(3)nanorobots(BTO NRs) immunologic barrier upstream driver rheumatoid arthritis(RA) 
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