Potential therapeutic targets from genetic and epigenetic approaches for asthma  

作　　者：Youming Zhang 

机构地区：[1]Genomic Medicine Section,National Heart and Lung Institute

出　　处：《World Journal of Translational Medicine》2016年第1期14-25,共12页世界转化医学杂志

摘　　要：Asthma is a complex disorder characterised by inflammation of airway and symptoms of wheeze and shortness of breath.Allergic asthma,atopic dermatitis and allergic rhinitis are immunoglobulin E(IgE) related diseases.Current therapies targeting asthma rely on non-specific medication to control airway inflammation and prevent symptoms.Severe asthma remains difficult to treat.Genetic and genomic approaches of asthma and Ig E identified many novel loci underling the disease pathophysiology.Recent epigenetic approaches also revealed the insights of DNA methylation and chromatin modification on histones in asthma and IgE.More than 30 micro RNAs have been identified to have regulating roles in asthma.Understanding the pathways of the novel genetic loci and epigenetic elements in asthma and IgE will provide new therapeutic means for clinical management of the disease in future.Asthma is a complex disorder characterised by inflammation of airway and symptoms of wheeze and shortness of breath.Allergic asthma,atopic dermatitis and allergic rhinitis are immunoglobulin E(IgE) related diseases.Current therapies targeting asthma rely on non-specific medication to control airway inflammation and prevent symptoms.Severe asthma remains difficult to treat.Genetic and genomic approaches of asthma and IgE identified many novel loci underling the disease pathophysiology.Recent epigenetic approaches also revealed the insights of DNA methylation and chromatin modification on histones in asthma and IgE.More than 30 micro RNAs have been identified to have regulating roles in asthma.Understanding the pathways of the novel genetic loci and epigenetic elements in asthma and IgE will provide new therapeutic means for clinical management of the disease in future.

关 键 词：ASTHMA IMMUNOGLOBULIN E GENOME-WIDE association studies EPIGENETICS MicroRNA 

分 类 号：R[医药卫生]