Tranexamic acid for the management of uterine fibroid tumors:A systematic review of the current evidence  

作　　者：Panagiotis Peitsidis Anna Koukoulomati 

机构地区：[1]Department of Obstetrics and Gynecology, Southend University Hospital, Essex SS0 0RY, United Kingdom [2]Department of Obstetrics and Gynecology, Iaso Maternity Hospital, 17123 Athens, Greece [3]Department of Obstetrics and Gynecology, Didymoteichon General Hospital, 68300 Didymoteicho, Greece

出　　处：《World Journal of Clinical Cases》2014年第12期893-898,共6页世界临床病例杂志

摘　　要：AIM: To conduct a detailed systematic review of the current evidence on the administration and efficacy of tranexamic acid in patients with menorrhagia due to uterine fibroids. METHODS: We conducted an electronic search on the following databases Pub Med and Medline(1950-2013);(1980-2013); Cochrane library(1993-2013). RESULTS: A total of 36 articles were retrieved after the initial electronic search. Careful assessment of the retrieved studies led to the final selection of 5 articles for inclusion in the review. CONCLUSION: Tranexamic acid may reduce blood loss perioperatively in myomectomies. It may reduce the menorrhagia in patients with fibroids, however a stratification of fibroids by size and location is required to define the responses. It is safe in general, with mild adverse effects observed in some cases. More studies with a double-blind randomized design and larger numbers of participants are necessary to reach more precise and safe conclusions.AIM: To conduct a detailed systematic review of the current evidence on the administration and efficacy of tranexamic acid in patients with menorrhagia due to uterine fibroids. METHODS: We conducted an electronic search on the following databases Pub Med and Medline(1950-2013);(1980-2013); Cochrane library(1993-2013). RESULTS: A total of 36 articles were retrieved after the initial electronic search. Careful assessment of the retrieved studies led to the final selection of 5 articles for inclusion in the review. CONCLUSION: Tranexamic acid may reduce blood loss perioperatively in myomectomies. It may reduce the menorrhagia in patients with fibroids, however a stratification of fibroids by size and location is required to define the responses. It is safe in general, with mild adverse effects observed in some cases. More studies with a double-blind randomized design and larger numbers of participants are necessary to reach more precise and safe conclusions.

关 键 词：Tranexamic acid UTERINE FIBROIDS FIBRINOLYSIS MENORRHAGIA MYOMECTOMY 

分 类 号：R737.33[医药卫生—肿瘤]