Hypoglycemia associated with fluoxetine treatment in a patient with type 1 diabetes  

作　　者：Betina Biagetti Rosa Corcoy 

机构地区：[1]Servei d’Endocrinologia i Nutrició, Hospital de la Santa Creu i Sant Pau, Avgda Sant Antoni M Claret 167, 08025 Barcelona, Spain [2]Departament de Medicina, Universitat Autònoma de Barcelona, 08193 Belllaterra, Spain [3]CIBER Bioengineering, Biomaterials and Nanotechnology, Instituto de Salud Carlos Ⅲ, 28029 Madrid, Spain

出　　处：《World Journal of Clinical Cases》2013年第5期169-171,共3页世界临床病例杂志

摘　　要：We report on a patient with type 1 diabetes mellitus who presented with recurrent episodes of hypoglycemia and a marked reduction in her daily insulin requirements after introduction of fluoxetine. This 25-yearold Caucasian woman had been followed up at the outpatient clinic for type 1 diabetes mellitus and prepregnancy care. She used a continuous subcutaneous insulin infusion with lispro and her daily insulin dose was 0.5 IU/kg per day. She had no chronic diabetic complications or hypoglycemia unawareness. Fluoxetine at a daily dose of 20 mg had been started because of depressive symptoms and within one week, she presented recurrent hypoglycemic episodes that prompted a progressive reduction in the insulin dose down to 0.3 IU/kg per day. The reduced insulin requirements continued during the period of fluoxetine treatment while glycated hemoglobin remained stable. She had no concurrent additional cause to explain the reduced insulin requirements. After fluoxetine was stopped, insulin re-quirements progressively increased and returned to the patient′s usual dose.We report on a patient with type 1 diabetes mellitus who presented with recurrent episodes of hypoglycemia and a marked reduction in her daily insulin requirements after introduction of fluoxetine. This 25-yearold Caucasian woman had been followed up at the outpatient clinic for type 1 diabetes mellitus and prepregnancy care. She used a continuous subcutaneous insulin infusion with lispro and her daily insulin dose was 0.5 IU/kg per day. She had no chronic diabetic complications or hypoglycemia unawareness. Fluoxetine at a daily dose of 20 mg had been started because of depressive symptoms and within one week, she presented recurrent hypoglycemic episodes that prompted a progressive reduction in the insulin dose down to 0.3 IU/kg per day. The reduced insulin requirements continued during the period of fluoxetine treatment while glycated hemoglobin remained stable. She had no concurrent additional cause to explain the reduced insulin requirements. After fluoxetine was stopped, insulin re-quirements progressively increased and returned to the patient′s usual dose.

关 键 词：FLUOXETINE Selective serotonin-reuptake INHIBITOR HYPOGLYCEMIA DIABETES MELLITUS 

分 类 号：R587.1[医药卫生—内分泌]