What have we learned about non-involved psoriatic skin from large-scale expression studies?  

作　　者：Eszter Szlavicz Kornelia Szabo Zsuzsanna Bata-Csorgo Lajos Kemeny Marta Szell 

机构地区：[1]Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary [2]Dermatological Research Group of the Hungarian Academy of Sciences, University of Szeged, H-6720 Szeged, Hungary [3]Department of Medical Genetics, the University of Szeged, H-6720 Szeged, Hungary

出　　处：《World Journal of Dermatology》2014年第3期50-57,共8页世界皮肤病学杂志

基　　金：Supported by OTKA NK77434,OTKA K 83277,OTKA K105985;TáMOP-4.2.2.A-11/1/KONV,TáMOP-4.2.2-B-10/1-2010-0012;the Bolyai Foundation of the Hungarian Academy of Sciences(to Kornelia Szabo)

摘　　要：Psoriasis is a chronic inflammatory skin disorder; its genetic background has been widely studied in recent decades. Recognition of novel factors contributing to the pathogenesis of this disorder was facilitated by potent molecular biology tools developed during the 1990 s. Large-scale gene expression studies, including differential display and microarray, have been used in experimental dermatology to a great extent; moreover, skin was one of the first organs analyzed using these methods. We performed our first comprehensive gene expression analysis in 2000. With the help of differential display and microarray, we have discovered several novel factors contributing to the inherited susceptibility for psoriasis, including the EDA+ fibronectin splice variant and PRINS. The long non-coding PRINS RNA is expressed at higher levels in non-involved skin compared to healthy and involved psoriatic epidermis and might be a factor contributing cellular stress responses and, specifically, to the development of psoriatic symptoms. This review summarizes the most important results of our large-scale gene expression studies.Psoriasis is a chronic inflammatory skin disorder; its genetic background has been widely studied in recent decades. Recognition of novel factors contributing to the pathogenesis of this disorder was facilitated by potent molecular biology tools developed during the 1990 s. Large-scale gene expression studies, including differential display and microarray, have been used in experimental dermatology to a great extent; moreover, skin was one of the first organs analyzed using these methods. We performed our first comprehensive gene expression analysis in 2000. With the help of differential display and microarray, we have discovered several novel factors contributing to the inherited susceptibility for psoriasis, including the EDA+ fibronectin splice variant and PRINS. The long non-coding PRINS RNA is expressed at higher levels in non-involved skin compared to healthy and involved psoriatic epidermis and might be a factor contributing cellular stress responses and, specifically, to the development of psoriatic symptoms. This review summarizes the most important results of our large-scale gene expression studies.

关 键 词：Non-involved psoriatic SKIN Differential display cDNA microarray EDA+fibronectin isoform PRINS long NON-CODING RNA mRNA maturation 

分 类 号：R[医药卫生]