Specificity in the alteration of lesional and non-lesional skin lipids in atopic dogs  

作　　者：Iuliana Popa Jacques Portoukalian Marek Haftek 

机构地区：[1]UMR 8612 CNRS, Faculty of Pharmacy, University Paris Sud XI [2]University of Lyon-1, Laboratory of Dermatological Research EA 4169

出　　处：《World Journal of Dermatology》2015年第1期1-7,共7页世界皮肤病学杂志

摘　　要：The present paper is in the same time an overview of the literature concerning the alterations of lipids in the stratum corneum(SC) of atopic dogs and a review of data based on our publications. Knowing the importance of the SC barrier function for against pathogens in atopic dermatitis, we show for the first time a detailed biochemical analysis of lipids corresponding to the same amount of proteins in the successive layers of canine SC taken using tape stripping and their specificity as compared to humans. Also we show new results concerning the changes in the composition for proteinbound ceramides, and for the other lipids in involved and non-involved skin areas in atopic dogs. We show how a topical or oral treatment can restore the SC lipid composition and reconstruct the barrier integrity by upregulating the biosynthesis of protein-bound ceramides.The present paper is in the same time an overview of the literature concerning the alterations of lipids in the stratum corneum(SC) of atopic dogs and a review of data based on our publications. Knowing the importance of the SC barrier function for against pathogens in atopic dermatitis, we show for the first time a detailed biochemical analysis of lipids corresponding to the same amount of proteins in the successive layers of canine SC taken using tape stripping and their specificity as compared to humans. Also we show new results concerning the changes in the composition for proteinbound ceramides, and for the other lipids in involved and non-involved skin areas in atopic dogs. We show how a topical or oral treatment can restore the SC lipid composition and reconstruct the barrier integrity by upregulating the biosynthesis of protein-bound ceramides.

关 键 词：ATOPIC DERMATITIS DOGS GLUCOSYLCERAMIDE LIPIDS CERAMIDE Stratum corneum 

分 类 号：R[医药卫生]