History of the infantile hepatic hemangioma:From imaging to generating a differential diagnosis  

作　　者：Maria Gnarra Gerald Behr Alison Kitajewski June K Wu Sudha A Anupindi Carrie J Shawber Nick Zavras Dimitrios Schizas Chris Salakos Konstantinos P Economopoulos 

机构地区：[1]Vascular Biology Program,Department of Surgery,Boston Children's Hospital and Harvard Medical School [2]Department of Radiology,Columbia University Medical Center [3]Department of Surgery,Columbia University Medical Center [4]Department of Radiology,the Children's Hospital of Philadelphia,University of Pennsylvania Perelman School of Medicine [5]Department of OB/GYN,Columbia University Medical Center [6]Department of Pediatric Surgical,"ATTIKO" General University Hospital [7]Society of Junior Doctors,Surgery Working Group [8]Department of Surgery,Massachusetts General Hospital,Harvard Medical School

出　　处：《World Journal of Clinical Pediatrics》2016年第3期273-280,共8页世界临床儿科杂志

摘　　要：We aim to provide an up-to-date summary of infantile hepatic hemangioma(IHH) and its misnomers and to dialectically present the differential diagnosis of these rare entities of the liver.Eligible peer-reviewed articles on hepatic infantile hemangiomas,published between 2000 and 2015,were reviewed for this study.IHH is the most common hepatic vascular tumor in children.Once a liver mass is identified in an infant,the differential diagnosis ranges from vascular malformations to benign and malignant tumors including mesenchymal hamartoma,hepatoblastoma,metastatic neuroblastoma,so careful physical examination,imaging studies,and,if indicated,tumor markers and biopsy,are of pivotal importance to ascertain the correct diagnosis.Despite the benign nature of IHHs,some of these lesions may demand medical and/or surgical intervention,especially for multiple and diffuse IHH.Complications can include hepatomegaly,hypothyroidism and cardiac failure.Therefore,a close follow-up is required until complete involution of the lesions.We propose an algorithm to guide the physicians towards the proper management of hepatic lesions.We aim to provide an up-to-date summary of infantile hepatic hemangioma(IHH) and its misnomers and to dialectically present the differential diagnosis of these rare entities of the liver.Eligible peer-reviewed articles on hepatic infantile hemangiomas,published between 2000 and 2015,were reviewed for this study.IHH is the most common hepatic vascular tumor in children.Once a liver mass is identified in an infant,the differential diagnosis ranges from vascular malformations to benign and malignant tumors including mesenchymal hamartoma,hepatoblastoma,metastatic neuroblastoma,so careful physical examination,imaging studies,and,if indicated,tumor markers and biopsy,are of pivotal importance to ascertain the correct diagnosis.Despite the benign nature of IHHs,some of these lesions may demand medical and/or surgical intervention,especially for multiple and diffuse IHH.Complications can include hepatomegaly,hypothyroidism and cardiac failure.Therefore,a close follow-up is required until complete involution of the lesions.We propose an algorithm to guide the physicians towards the proper management of hepatic lesions.

关 键 词：Hepatic HEMANGIOMAS INFANT Children VASCULAR TUMORS 

分 类 号：R735.7[医药卫生—肿瘤]