Understanding the pathophysiology of postpartum psychosis: Challenges and new approaches  

作　　者：William Davies 

机构地区：[1]Medical Research Council Centre for Neuro-psychiatric Genetics and Genomics and Division of Psychological Medicine and Clinical Neurosciences, School of Medicine, Cardiff University [2]School of Psychology, Cardiff University [3]Neuroscience and Mental Health Research Institute, Cardiff University

出　　处：《World Journal of Psychiatry》2017年第2期77-88,共12页世界精神病学杂志

基　　金：Supported by Medical Research Council Centre for Neuro-psychiatric Genetics and Genomics,No.MR/L010305/1

摘　　要：Postpartum psychosis is a severe psychiatric condition which affects 1-2 of every 1000 mothers shortly after childbirth. Whilst there is convincing evidence that the condition is precipitated by a complex combination of biological and environmental factors, as yet the pathophysiological mechanisms remain extremely poorly defined. Here, I critically review approaches that have been, or are being, employed to identify and characterise such mechanisms; I also review a recent animal model approach, and describe a novel biological risk model that it suggests. Clarification of biological risk mechanisms underlying disorder risk should permit the identification of relevant predictive biomarkers which will ensure that "at risk" subjects receive prompt clinical intervention if required.Postpartum psychosis is a severe psychiatric condition which affects 1-2 of every 1000 mothers shortly after childbirth. Whilst there is convincing evidence that the condition is precipitated by a complex combination of biological and environmental factors, as yet the pathophysiological mechanisms remain extremely poorly defined. Here, I critically review approaches that have been, or are being, employed to identify and characterise such mechanisms; I also review a recent animal model approach, and describe a novel biological risk model that it suggests. Clarification of biological risk mechanisms underlying disorder risk should permit the identification of relevant predictive biomarkers which will ensure that "at risk" subjects receive prompt clinical intervention if required.

关 键 词：CCN3 Immune system STEROID SULFATASE Nephroblastoma-overexpressed Mouse ANIMAL model Risk factor 

分 类 号：R749[医药卫生—神经病学与精神病学]