From the battlefield to the bladder: The development of thio TEPA  

作　　者：Sean M Gallagher Steven H Selman 

机构地区：[1]Department of Urology, The University of Toledo College of Medicine and Life Sciences,Toledo, OH 43614, United States [2]Department of Urology, University of Toledo Medical Center,Toledo, OH 43614, United States

出　　处：《World Journal of Clinical Urology》2014年第3期195-200,共6页世界临床泌尿杂志

基　　金：Supported by The Frank D Stranahan Endowment for Oncologic Research

摘　　要：Effective medications for the treatment of cancer were nonexistent in the early twentieth century.Ironically the widespread use of toxic chemical weapons,chlorine and sulfur mustard gas,during the"Great War"led to the first successful chemotherapeutic treatment of cancer patients.Soon after the introduction of poisonous gas on the battlefield,reports of the resulting pancytopenia in exposed combatants appeared in the medical literature.The biologic effect of chemical weaponry on rapidly dividing cells eventually was recognized for its salutary potential in the treatment of cancer.Once this potential was appreciated,hundreds of similar compounds were synthesized and evaluated as chemotherapeutic agents.One such compound,thioT EPA,would eventually open the era of intravesical treatment of urothelial cancer.Effective medications for the treatment of cancer were nonexistent in the early twentieth century.Ironically the widespread use of toxic chemical weapons,chlorine and sulfur mustard gas,during the"Great War"led to the first successful chemotherapeutic treatment of cancer patients.Soon after the introduction of poisonous gas on the battlefield,reports of the resulting pancytopenia in exposed combatants appeared in the medical literature.The biologic effect of chemical weaponry on rapidly dividing cells eventually was recognized for its salutary potential in the treatment of cancer.Once this potential was appreciated,hundreds of similar compounds were synthesized and evaluated as chemotherapeutic agents.One such compound,thioT EPA,would eventually open the era of intravesical treatment of urothelial cancer.

关 键 词：ThioTEPA BLADDER CANCER UROTHELIAL CANCER INTRAVESICAL chemotherapy MUSTARD gas MITOMYCIN C 

分 类 号：R[医药卫生]