Hypocretin(orexin) pathology in Alzheimer's disease  

作　　者：Thomas C Thannickal 

机构地区：[1]Department of Psychiatry and Biobehavioral Sciences, University of California [2]Veterans Administration Greater Los Angeles Healthcare System, Neurobiology Research (151A3)

出　　处：《World Journal of Neurology》2015年第3期64-67,共4页世界神经病学杂志

摘　　要：Alzheimer's disease(AD) is a growing health problem. It has enormous public health impact. Sleep problems show an early component of this disease. Hypocretin hasa major function in sleep-wake cycle. The total number of hypocretin neurons in the normal humans ranges from 51000-83000, located exclusively in the hypothalamus. Deficiency in hypocretins neurotransmission results in narcolepsy, Parkinson's disease, and other neurological and psychological disorders. Cerebrospinal fluid(CSF) hypocretin levels were directly related with t-tau protein amount in AD. Increased hypocretin CSF in AD suggest that hypocretin is involved in the mechanism of AD pathology.Alzheimer's disease(AD) is a growing health problem. It has enormous public health impact. Sleep problems show an early component of this disease. Hypocretin hasa major function in sleep-wake cycle. The total number of hypocretin neurons in the normal humans ranges from 51000-83000, located exclusively in the hypothalamus. Deficiency in hypocretins neurotransmission results in narcolepsy, Parkinson's disease, and other neurological and psychological disorders. Cerebrospinal fluid(CSF) hypocretin levels were directly related with t-tau protein amount in AD. Increased hypocretin CSF in AD suggest that hypocretin is involved in the mechanism of AD pathology.

关 键 词：HYPOCRETIN OREXIN Alzheimer’s disease NEUROLOGICAL DISORDERS 

分 类 号：R749.16[医药卫生—神经病学与精神病学]