PHD2和HIF-1α与子宫内膜癌临床病理参数的相关性研究  

Correlation of PHD2 and HIF-1α with clinicopathological features of endometrial carcinoma

作　　者：未亚兰 朱诚程 张莹[1] 丁锦[1] 李佳嘉[2] 倪观太[1] WEI Ya-lan(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Wannan Medical College,Wuhu241001,China)

机构地区：[1]皖南医学院第一附属弋矶山医院妇产科,安徽芜湖241001 [2]皖南医学院第一附属弋矶山医院病理科,安徽芜湖241001

出　　处：《牡丹江医学院学报》2018年第6期1-4,共4页Journal of Mudanjiang Medical University

基　　金：皖南医学院中青年科研基金(WK2017F30)

摘　　要：目的探讨子宫内膜癌中脯氨酸羟化酶(proline hydroxylase domain2,PHD2)、缺氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)蛋白表达与其临床病理参数的相关性。方法采用Envision法测定PHD2和HIF-1α蛋白在正常子宫内膜、子宫内膜增生症、子宫内膜癌组织中的表达。结果 PHD2阳性表达在子宫内膜癌组为32.5%,比正常子宫内膜组(100%,P<0.05)及子宫内膜增生症组(100%,P<0.05)显著低表达; HIF-1α阳性表达在子宫内膜癌组为67.5%,比正常子宫内膜组(15%,P<0.05)及子宫内膜增生症组(30%,P<0.05)显著高表达; PHD2、HIF-1α蛋白表达在子宫内膜癌FIGO分期及淋巴结转移方面有统计学差异(P<0.05)。结论 PHD2和HIF-1α表达情况可能与子宫内膜癌病程进展存在相关性。Objective To explore the relationships between the expressions of proline hydroxylase domain 2 and hypoxia-inducible factor-1αin endometrial carcinoma and its clinicopathological parameters.Methods The PHD2 and HIF-1αprotein expression in normal endometrium,endometrial hyperplasia and endometrial carcinoma were detected by Envision.Results The positive expression rate of PHD2 in endometrial cancer group was32.5%,significantly lower than that in normal endometrial group(100%,P<0.05)and endometrial hyperplasia group(100%,P<0.05);Positive expression rate of HIF-1αin endometrial carcinoma group was 67.5%,significantly higher than that in normal endometrial group(15%,P<0.05)and endometrial hyperplasia group(30%,P<0.05);PHD2 and HIF-1α were statistically different in clinical stage and lymph node metastasis of endometrial carcinoma(P<0.05).Conclusion The expression of PHD2 and HIF-1αmaybe closely related to the progression of endometrial cancer.

关 键 词：子宫内膜癌 子宫内膜复杂性增生 子宫内膜不典型增生 PHD2 HIF-1Α 

分 类 号：R737.33[医药卫生—肿瘤]