supported by grants from the National Natural Science Foundation of China(No.81400695);the Anhui Provincial Natural Science Foundation,China(No.1508085QH153);the Foundation of Wannan Medical College,China(No.WK201401)
剪切型X盒结合蛋白1(spliced X-box binding protein 1,XBP1S)是内质网应激关键信号分子。有研究表明XBP1S在肾脏系膜细胞具有抗氧化应激和抗凋亡作用,而氧化应激是肾纤维化发生发展重要因素。缬沙坦(valsartan)具有改善肾纤维化作用。...