supported by the National Natural Science Foundation of China (No. 81400695);the Natural Science Foundation of Anhui Province,China (No. 1508085QH153, 1908085QC132);the Natural Science Research Project Fund for Colleges and Universities in Anhui Province,China (No. KJ2019A0408);the Foundation of Wannan Medical College (No. WK202024)。
肾小管上皮细胞死亡是急性肾损伤(acute kidney injury, AKI)的重要原因。本文旨在研究由Gasdermin D (GSDMD)介导的细胞焦亡是否参与脂多糖(lipopolysaccharide, LPS)诱导的脓毒症AKI,并探讨caspase-1、caspase-11焦亡通路在其中的作...