^(18)F标记的正电子药物中氨基聚醚(2.2.2)测定方法研究  

Detection of Kryptofix 2.2.2 in ^(18)F-labeled PET radiopharmaceuticals

作　　者：姚静[1] 贾娟娟[1] 弓全胜 许晓平 袁慧瑜 施亚琴[1] YAO Jing;JIA Juanjuan;GONG Quansheng;XU Xiaoping;YUAN Huiyu;SHI Yaqin(National Institutes for Food and Drug Control,Beijing 102629,China;Department of Nuclear Medicine,Fudan University Shanghai Cancer Center,Shanghai 200032,China)

机构地区：[1]中国食品药品检定研究院,北京102629 [2]复旦大学附属肿瘤医院核医学科,上海200032

出　　处：《肿瘤影像学》2018年第6期433-436,共4页Oncoradiology

基　　金：国家重大新药创制--化药制剂质量评价关键技术研究(2015ZX09303001)

摘　　要：目的:建立^(18)F标记的正电子药物中氨基聚醚(Kryptofix2.2.2)的快速测定方法。方法:以经过碘铂酸盐试剂预处理的硅胶G板为载体,将^(18)F标记的正电子药物供试品溶液和氨基聚醚(2.2.2)对照溶液点于薄层板上进行显色。结果:氨基聚醚(2.2.2)对照溶液在斑点中心显深蓝色的圆或圆环;供试品溶液中如有氨基聚醚(2.2.2),在斑点中心显深蓝色圆或圆环。结论:该方法操作简便、快速、灵敏度高且重复性好,适用于^(18)F标记的正电子药物中氨基聚醚(2.2.2)的快速检测。Objective:To establish a method for rapid detection of Kryptofix 2.2.2 in 18F-labeled PET radiopharmaceuticals.Methods:Pretreated thin layer chromatography(TLC)silica gel plates,saturated with iodoplatinate reagent,were the medium.The 18F-labeled imaging agents and standard solutions were applied on the pretreated plate and the spots were visually compared.Results:There was a dark blue circle or ring in the center of the spot for standard solution.The similar spot would appeare if the test solution had Kryptofix 2.2.2.Conclusion:The method is simple,rapid,sensitive,repeatable and suitable for the detection of Kryptofix 2.2.2 in 18F-labeled PET radiopharmaceuticals.

关 键 词：氨基聚醚(2.2.2) 18F-FDG 18F-FES 18F-FLT 

分 类 号：R73-34[医药卫生—肿瘤]