Castleman disease presenting with jaundice: A case report and review of literature  

作　　者：Bo Zhai Hai-Yang Ren Wei-Dong Li Shiva Reddy Shu-Jun Zhang Xue-Ying Sun 

机构地区：[1]Department of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University [2]Hepatosplenic Surgery Center, The First Affiliated Hospital of Harbin Medical University [3]Department of Molecular Medicine and Pathology, Faculty of Medical and Health Sciences, The University of Auckland [4]Department of Pathology, The Fourth Affiliated Hospital of Harbin Medical University

出　　处：《World Journal of Clinical Cases》2019年第3期373-381,共9页世界临床病例杂志

基　　金：Supported by the National Key Research and Development Program of China,No.2017YFC1308602;the National Natural Scientific Foundation of China,No.81472321 and No.81401975

摘　　要：BACKGROUND Castleman disease(CD) is a rare lymphoproliferative disorder that presents with various symptoms. CD accompanied with jaundice is uncommon since there are only 11 cases reported in the literature.CASE SUMMARY Here we report a 62-year-old woman who was admitted to the hospital with signs and symptoms of intermittent jaundice. Biochemical tests showed higher serum levels of total and direct bilirubin, and normal serum levels of tumor markers and interleukin-6. Contrast-enhanced computed tomography detected a6 cm × 4 cm × 2.5 cm mass between the hepatoduodenal ligament and the inferior vena cava. The mass was successfully excised and the patient had a complete resolution of symptoms. A diagnosis of idiopathic unicentric CD was made based upon histological examination, which demonstrated the pathological features of CD of mixed type, including hyperplasia of follicular lymphoids with abundant plasma cells, degenerative germinal centers, interfollicular vascularity and hyaline degeneration. The diagnosis was corroborated by immunohistochemical analysis which detected multiple biomarkers.CONCLUSION This is the first study that describes the clinicopathological features of CD presenting with jaundice, which may deepen and extend our understanding of this disease.BACKGROUND Castleman disease(CD) is a rare lymphoproliferative disorder that presents with various symptoms. CD accompanied with jaundice is uncommon since there are only 11 cases reported in the literature.CASE SUMMARY Here we report a 62-year-old woman who was admitted to the hospital with signs and symptoms of intermittent jaundice. Biochemical tests showed higher serum levels of total and direct bilirubin, and normal serum levels of tumor markers and interleukin-6. Contrast-enhanced computed tomography detected a6 cm × 4 cm × 2.5 cm mass between the hepatoduodenal ligament and the inferior vena cava. The mass was successfully excised and the patient had a complete resolution of symptoms. A diagnosis of idiopathic unicentric CD was made based upon histological examination, which demonstrated the pathological features of CD of mixed type, including hyperplasia of follicular lymphoids with abundant plasma cells, degenerative germinal centers, interfollicular vascularity and hyaline degeneration. The diagnosis was corroborated by immunohistochemical analysis which detected multiple biomarkers.CONCLUSION This is the first study that describes the clinicopathological features of CD presenting with jaundice, which may deepen and extend our understanding of this disease.

关 键 词：CASTLEMAN DISEASE JAUNDICE Case report CLINICOPATHOLOGY IMMUNOHISTOCHEMISTRY 

分 类 号：R[医药卫生]