磷酸化组蛋白H3在肿瘤中的研究进展  

Progress of phosphohistone H3 in tumors

作　　者：李小红[1] 付蓉[1] 张雨涛[1] Li Xiaohong;Fu Rong;Zhang Yutao(Department of Pathology,Zigong First People's Hospital,Zigong 643000,China)

机构地区：[1]四川省自贡市第一人民医院病理科,643000

出　　处：《肿瘤研究与临床》2019年第1期66-68,共3页Cancer Research and Clinic

摘　　要：磷酸化组蛋白H3(PHH3)是新近发现的五个核心组蛋白之一,在真核细胞中与其他组蛋白构成染色质中的主要蛋白组分。PHH3在有丝分裂的G2期及M期达到最大值,因此被认为是一种特异性的核分裂标志物。目前PHH3已经被证实对确定肿瘤细胞的核分裂象,区分核分裂象和凋亡小体、核碎片非常有用。文章就PHH3在肿瘤中的研究现状进行综述。Phosphohistone H3(PHH3)is one of the five newly discovered nucleocardial histones.PHH3 with other histones constitute the main protein components in chromatin in eukaryotic.For it reached the maximum value in G2 phase and M phase with mitosis,so it was considered as a specific nuclear fission marker.At present,PHH3 has been proved to be very useful to determine the nuclear fission images of tumor cells,and to distinguish the nuclear fission images from apoptotic bodies and nuclear fragments.This paper reviews the research status of PHH3 in tumors.

关 键 词：肿瘤 磷酸化组蛋白H3 有丝分裂 

分 类 号：R730.2[医药卫生—肿瘤]