Wnt信号通路与慢性粒细胞白血病  

Wnt Signaling Pathway and Chronic Myelogenous Leukemia

作　　者：侯艳 李文倩[2] 冯建明[2] 艾国[2] 解友邦[2] 华青措 赵长明 HOU Yan;LI Wenqian;FENG Jianming;AI Guo;XIE Youbang;HUA Qingcuo;ZHAO Changming(Graduate School,Qinghai University,Xi’ning 810016,China;Department of Blood Rheumatology,Qinghai Provincial People's Hospital,Xi’ning 810007,China)

机构地区：[1]青海大学研究生院,西宁810016 [2]青海省人民医院血液风湿科,西宁810007

出　　处：《肿瘤防治研究》2019年第2期174-177,共4页Cancer Research on Prevention and Treatment

基　　金：青海省卫生计生委科研课题和适宜技术推广项目(2016-wjzdx-17);青海省卫生计生委指导性科研课题(2016-wjzdx-16);青海省人才"小高地"项目(青人才字[2014]12号);国家临床重点专科建设项目(卫办医政函[2011]873号)

摘　　要：慢性粒细胞白血病作为血液系统的恶性增殖性肿瘤,其主要发病机制为BCR-ABL1融合基因形成,因此针对BCR-ABL1基因的靶向药物TKI为其治疗带来了希望,但TKI无法完全消除CML患者体内的LSCs,CML患者容易出现TKI药物耐药及治疗后复发。随着Wnt信号通路在实体瘤中的应用,大量研究发现Wnt信号通路同样在CML中起到重要作用,我们就Wnt信号通路对CML的影响作一综述。As a type of cancer that starts in certain blood-forming cells of the bone marrow,chronic myeloid leukemia(CML)is caused by the formation of an abnormal gene called BCR-ABL1.The targeted medicine TKI for BCR-ABL1 has great effect on treating CML:however,TKI is not able to completely remove the leukemia stem cells(LSCs)in CML patients,which will lead to drug resistance and leukemia relapse.With the application of Wnt signaling pathway in regulating stem cell function,many studies have found that it also plays an important role in treating CML.In this paper,we reviewed the impact of Wnt signaling pathway on CML therapy.

关 键 词：慢性粒细胞白血病 WNT信号通路 白血病干细胞 TKI 

分 类 号：R733.72[医药卫生—肿瘤]